ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension.

CONCLUSIONS: Increased 4-hydroxynonenal level plays a critical role in the development of HPH. ALDH2 attenuates the development of HPH by regulating mitochondrial fission and smooth muscle cell proliferation suggesting ALDH2 as a potential new therapeutic target for pulmonary hypertension. PMID: 31510791 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research

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AbstractBackgroundBariatric surgery on patients with body mass index (BMI)  ≥ 50 kg/m2, historically known as superobesity, is technically challenging and carries a higher risk of complications. Bridging interventions have been introduced for weight loss before bariatric surgery in this population. This systematic review and meta-analysis aims to assess the efficacy and safety of bridging interventions before bariatric surgery in patients with BMI  ≥ 50 kg/m2.MethodsMEDLINE, EMBASE, Web of Science, and Scopus were searched from database inception to September 2018. Studies were e...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Source: Patient Preference and Adherence - Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
AbstractObjectiveTo study lipiodol deposition in portal vein tumour thrombus (PVTT) in predicting the treatment outcome of hepatocellular carcinoma (HCC) patients after transarterial chemoembolisation (TACE).MethodsWe retrospectively reviewed data from 379 HCC patients with PVTT who underwent TACE as the initial treatment at Sun Yat-Sen University Cancer Center from January 2008 to December 2015. Patients were grouped by positive and negative lipiodol deposition based on the extent of lipiodol deposition in PVTT. The overall survival (OS) and progression-free survival (PFS) were compared between negative and positive lipio...
Source: European Radiology - Category: Radiology Source Type: research
ConclusionsMultilingual structured reporting templates may serve as a feasible tool for creating high-quality radiology reports in foreign languages.Key Points• Multilingualism in structured reporting templates can be a useful tool for creating high-quality radiology reports in foreign languages.•German reports created with multilingual structured reporting templates by English-speaking radiologists and German structured reports by German radiologists exhibit no significant differences in overall report quality.•Multilingual structured reporting templates can help radiologists overcome communication barriers...
Source: European Radiology - Category: Radiology Source Type: research
Authors: Snopkova S, Matyskova M, Havlickova K, Jarkovsky J, Svoboda M, Zavrelova J, Svacinka R, Penka M, Husa P Abstract OBJECTIVES: HIV-infected individuals are at higher risk of non-AIDS diseases associated with procoagulant status. Microparticles are elevated in disorders associated with thrombosis (e.g., cardiovascular diseases). We investigated the association between microparticle levels in untreated and treated HIV-infected subjects, and determined the association with immune status, viral replication, and duration of antiretroviral therapy. PATIENTS AND METHODS: We included 144 HIV-infected subjects, i...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Publication date: December 2019Source: Biomedicine &Pharmacotherapy, Volume 120Author(s): Alberto Mazza, Danyelle M. Townsend, Laura Schiavon, Gioia Torin, Salvatore Lenti, Ciro Rossetti, Gianluca Rigatelli, Domenico RubelloAbstractBackgroundMost antihypertensive drugs used in monotherapy or in combination therapy reduce the left ventricular mass index (LVMI). However, little is known about the effects on LVMI of a triple fixed-dose combination (TFC) therapy, containing in a single pill an angiotensin-converting enzyme inhibitor (ACEI), a diuretic and a calcium channel blocker (CCB).MethodsIn this prospective open-labe...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionSalvianolic acid B has a protective effect on TAO rats. The mechanism may involve inhibition of thrombosis and TAO-associated inflammatory responses, which may explain the success of RSMA treatment of TAO in humans in traditional Chinese medical practice. Hence, it may be a potential drug for TAO treatment in conventional medicine.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
We report here the first successful transcatheter implantation of a stented valve in a pulmonary position in a dog with congenital pulmonary valve disease. A 3-year-old, 10.9 kg, client-owned Beagle dog was referred for a follow-up visit after a percutaneous balloon valvuloplasty performed 22 months before for treatment of a severe type A valvular pulmonary stenosis. The Doppler-derived peak pressure gradient (PG) was 348 mmHg before the procedure and 66 mmHg 24 hours after. The dog was lethargic. Echocardiography revealed a mild pulmonary stenosis (PG - 43 mmHg), severe pulmonary regurgitation, and secondary severe right ...
Source: Journal of Veterinary Cardiology - Category: Veterinary Research Source Type: research
Conditions:   Retinitis Pigmentosa;   Maculopathy, Age Related;   Macular Dystrophy;   Macular Edema;   Retinal Detachment;   Retinal Degeneration;   Glaucoma;   Vascular Inflammation;   Hypertension;   Stroke;   Diabetes;   Corneal Dystrophy;   Keratoconus;   Dry Eye;   Trauma Interventions:   Device: High-resolution retinal imaging through adaptive optics;   Device: High-resolution retinal imaging through holographic systems Sponsor:   Centre Hospitalier National d'Ophtalmologie des ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Venous Thromboses;   Stent Stenosis Intervention:   Drug: Aspirin 100mg Sponsor:   University of Zurich Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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