Tolerogenic Dendritic Cell Transfer Ameliorates Systemic Lupus Erythematosus in Mice.

In conclusion, these results suggest that the transfer of histone-loaded tolDCs could improve only some SLE symptoms and reduced anti-nuclear antibodies. This is the first study to evaluate antigen-specific tolDCs administration to treat SLE. Our report strengthens the clinical relevance of tolDCs generation with CoPP, dexamethasone and rosiglitazone and the use of these modified cells as a therapy for systemic autoimmunity.
PMID: 31509246 [PubMed - as supplied by publisher]

Source: Immunology - September 10, 2019 Category: Allergy & Immunology Authors: Funes SC, Ríos M, Gómez-Santander F, Fernández-Fierro A, Altamirano-Lagos MJ, Rivera-Perez D, Pulgar-Sepúlveda R, Jara EL, Rebolledo-Zelada D, Villarroel A, Roa JC, Mackern-Oberti JP, Kalergis AM Tags: Immunology Source Type: research