Comparison of subjective, objective and patient-reported cosmetic outcomes between accelerated partial breast irradiation and whole breast radiotherapy: a prospective propensity score-matched pair analysis.

CONCLUSIONS: Overall cosmetic outcomes as well as individual subdomains are significantly better with APBI as compared to WBRT by all methods of assessment of cosmesis when matched for various factors. PMID: 31512161 [PubMed - as supplied by publisher]
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research

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Abstract BACKGROUND: Survivorship care plans (SCPs) have been used to address ongoing health problems associated with the diagnosis and treatment of early-stage breast cancer. OBJECTIVES: The aim of this article was to determine whether nurse-led consultations using SCPs, as compared with a standard medical consultation, identify more side effects and supportive care needs and lead to appropriate referral patterns. METHODS: The study audited 160 retrospective medical clinic and nursing SCP records in a sample of patients receiving treatment for early-stage breast cancer at a tertiary-level breast service...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Clin J Oncol Nurs Source Type: research
ConclusionOverweight/obese breast cancer patients may be more prone to breast WAT inflammation and may be associated with abnormalities in circulatory markers associated with metabolic syndrome.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
AbstractThoracic endometriosis-related pneumothorax (TERP) or thoracic endometriosis syndrome (TES) usually occurs in women of childbearing age and affects the right thorax. Menopausal and left-sided cases are rare. A case of left-sided TERP in a postmenopausal woman after adjuvant endocrine therapy for breast cancer is reported. A 51-year-old woman underwent video-assisted thoracic surgery for recurrent left pneumothorax. Immunohistological examination of the resected specimen from the apical bleb and a diaphragmatic blueberry spot demonstrated thoracic endometriosis. Even in the case of a left-sided pneumothorax in a men...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Conclusions: These findings demonstrate that the high expression of SIRT7 indicates poor prognosis in breast cancer as well as increased immune infiltration levels of M1 macrophages and T cell exhaustion in breast cancer-luminal. Thus, SIRT7 may serve as a candidate prognostic biomarker for determining prognosis associated with immune infiltration in breast cancer-luminal.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Radiotherapy for left-sided breast cancer is associated with an increased risk of Coronary Artery Disease (CAD) which is proportional to the mean dose to the heart [1,2]. This counts for younger breast cancers survivors as well [3]. When patients also received anthracycline-containing chemotherapy an even higher increased risk of heart disease was observed [4]. Apart from that, cardiovascular disease (CVD) is the most important cause of death in women [5]. Finally, it appears that the death rate due to breast cancer decreases around time of menopause whereas the age-specific CVD death rate increases steadily across the lifespan [6].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Condition:   Focus of Study is Healthy Women at Risk for Breast Cancer Intervention:   Drug: DUAVEE 0.45Mg-20Mg Tablet Sponsors:   Carol Fabian, MD;   Breast Cancer Research Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractReliable determination of Ki67 labeling index (Ki67-LI) on core needle biopsy (CNB) is essential for determining breast cancer molecular subtype for therapy planning. However, studies on agreement between molecular subtype and Ki67-LI between CNB and surgical resection (SR) specimens are conflicting. The present study analyzed the influence of clinicopathological and sampling-associated factors on agreement. Molecular subtype was determined visually by Ki67-LI in 484 pairs of CNB and SR specimens of invasive estrogen receptor (ER) –positive, human epidermal growth factor (HER2)–negative breast cancer. L...
Source: Virchows Archiv - Category: Pathology Source Type: research
Conclusions: Ultra-low dose 0.005% estriol vaginal gel showed efficacy in improving the symptoms and signs of vulvovaginal atrophy. These results, together with minimal oscillations in hormonal levels throughout the treatment, support the use of ultra-low dose 0.005% estriol vaginal gel as a treatment option for vulvovaginal atrophy in women with breast cancer receiving NSAIs with an indication for treatment with vaginal estrogens. Video Summary:http://links.lww.com/MENO/A531.
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
Objective: Taiwanese women are younger than women in western countries when diagnosed with breast cancer, and many of them are still menstruating. One of many distressing side effects reported by premenopausal women treated for breast cancer are hot flashes (HFs). The purposes of this study were to identify: (1) the trajectories of hot flash (HF) occurrence, frequency, and interference and (2) potential factors associated with HF changes. Methods: Peri- or premenopausal women newly diagnosed with breast cancer scheduled to receive chemotherapy and hormonal therapy were enrolled. HF frequency, HF interference, and othe...
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
Menopause is often associated with a central accumulation of body fat [1]. This may provoke insulin resistance, leading to hyperinsulinemia [2]. An increased insulin level is a risk factor for diabetes [3,4] and cardiovascular disease [5]. Moreover, the Women ’s Health Initiative (WHI) trial revealed that hyperinsulinemia is an independent risk factor for postmenopausal breast cancer [6]. As obese postmenopausal women have higher levels of estrogen, it is believed that estrogens are linked to increased breast cancer risk.
Source: Maturitas - Category: Primary Care Authors: Source Type: research
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