Suicidal Behavior in Psoriasis: The Case of Brodalumab Suicidal Behavior in Psoriasis: The Case of Brodalumab

Suicidal ideation has been reported in psoriasis patients treated with brodalumab, which led to a black box warning. Is there enough evidence to establish causality, or are other factors involved?Skin Therapy Letter
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Related Links:

AbstractHidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. Clinicians should be informed about these comorbidities so that appropriate screening is implemented. All this evidence suggests that for such a chronic, multi-comorbid disease, the use of validated outcomes to assess severi...
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
Patients with psoriasis have high rates of depression and may be at increased risk for suicidal ideation and behavior (SIB). Attempted and completed suicides during clinical trials and other studies of psoriasis therapies, including brodalumab, highlight t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Authors: Esposito M, Giunta A, Del Duca E, Manfreda V, Troisi A, Bianchi L, Fargnoli MC Abstract Patients with psoriasis are at increased risk for psychiatric comorbidities, including suicidal ideation and behavior. For this reason, a careful assessment of patients, in particular for those reporting history of psychiatric symptoms is needed. We herein report a case series of 3 patients affected by major psychiatric disorders and moderate-to-severe psoriasis, successfully treated with secukinumab, an IL17A inhibitor, with a long-term psychiatric disease stability. PMID: 31916470 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
ConclusionIn a Taiwanese setting, no link between psoriasis or psoriatic arthritis and suicidal behavior was detected.
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
AbstractBackgroundChronic inflammatory diseases such as psoriasis require treatment options that maintain efficacy and tolerability during extended treatment.ObjectiveThe aim of the study was to assess the long-term efficacy and safety of brodalumab, a fully human anti-interleukin-17 receptor A monoclonal antibody, in patients with moderate-to-severe plaque psoriasis.MethodsPatients who completed a 12-week, phase II, dose-ranging clinical trial received brodalumab 210  mg every 2 weeks in an open-label extension study. Efficacy was assessed by static physician’s global assessment (sPGA) and psoriasis area a...
Source: American Journal of Clinical Dermatology - Category: Dermatology Source Type: research
Abstract The interleukin (IL)-17 inhibitors have proven to be highly effective in the treatment of psoriasis. The most recently approved agent, brodalumab, had few cases of suicidal behavior, including completed suicide, in the phase 3 clinical program leading both the US FDA and Health Canada to add a boxed warning to its label. This raises the importance of identifying the psychiatric comorbidities associated with psoriasis. It is also necessary to critically examine the data from the brodalumab clinical trial program to determine whether there is enough information to establish causality and whether other facto...
Source: Skin Therapy Letter - Category: Dermatology Authors: Tags: Skin Therapy Lett Source Type: research
CONCLUSION: Singh et al. concluded that patients with psoriasis have a significantly higher risk of suicidal ideation, suicide attempts, and completed suicides, while Chi et al concluded that the available limited, very low-quality evidence does not support the notion of an association between psoriasis on the one hand, and suicide, suicidal ideation and attempts on the other. This article is protected by copyright. All rights reserved. PMID: 31074832 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
CONCLUSION: Psychiatric and physical disorders carried greatly increased risks and numbers of suicides in South Korea. Schizophrenia was the strongest risk factor, especially 35-65 years, and depression was the most common in suicide victims among ICD-10 disorders in South Korea. PMID: 31042694 [PubMed]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
To the Editor: Significantly increased risks for depression and suicidality have been found in psoriasis patients,1 and psoriasis has been independently associated with major depression.2 Therefore, it is important to be able to identify depression and suicidal ideation and behavior (SIB) among psoriasis patients. Standardized screening tools, such as the Patient Health Questionnaire-2 (PHQ-2), enable rapid identification of depression and SIB within minutes, making screening feasible, efficient, and effective in the outpatient setting.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
This study examined the risks of a range of adverse events in a large cohort of patients prescribed long‐term opioids using the UK Clinical Practice Research Datalink.MethodsPatients with musculoskeletal conditions starting a new long ‐term opioid episode (defined as ≥3 opioid prescriptions within 90 days) between 2002‐2012 were included. Primary outcomes: major trauma and intentional overdose (any). Secondary outcomes: addiction (any), falls, accidental poisoning, attempted suicide/self‐harm, gastrointestinal pathology a nd bleeding, and iron deficiency anaemia. ‘Control’ outcomes (unrelated to opio...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
More News: Depression | Dermatology | Health | Psoriasis | Skin | Suicide | Warnings