Metagenomic data screening reveals the distribution of mobilized resistance genes tet(X), mcr and carbapenemase in animals and humans

In March, 2019, The Journal of Infection published our finding1 that live poultry markets (LPMs) is a huge antibiotic resistance gene (ARGs) reservoir, including the plasmid-mediated colistin resistance gene mcr-1, which have been in the human gut for a long time.2 Recently, a novel mobilized mcr-9 in a multidrug-resistant (MDR) Salmonella enterica Serotype Typhimurium isolate was reported.3 The Gram-negative bacteria co-producing mcr genes and carbapenemases limits our choice for treating MDR infections, however, tigecycline has been considered as the last-resort antibiotic.

Source: Journal of Infection - September 11, 2019 Category: Infectious Diseases Authors: Yanan Wang, Fei Liu, Baoli Zhu, George Fu Gao Tags: Letter to the Editor Source Type: research