Fragment-based screening with natural products for novel anti-parasitic disease drug discovery

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Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research

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Conclusion: This current study aims to establish PLG and VTN as novel diagnostic and prognostic protein biomarker for MAC and POLY PKDL cases management.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Abstract Multicellular eukaryotes emerged late in evolution from an ocean of viruses, bacteria, archaea, and unicellular eukaryotes. These macroorganisms are exposed to and infected by a tremendous diversity of microorganisms. Those that are large enough can even be infected by multicellular fungi and parasites. Each interaction is unique, if only because it operates between two unique living organisms, in an infinite diversity of circumstances. This is neatly illustrated by the extraordinarily high level of interindividual clinical variability in human infections, even for a given pathogen, ranging from a total absence ...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 25 May 2020Source: International Journal for Parasitology: Parasites and WildlifeAuthor(s): Alan J. Lymbery, Samuel J. Lymbery, Stephen J. Beatty
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
Publication date: Available online 25 May 2020Source: International Journal for Parasitology: Parasites and WildlifeAuthor(s): Ralph Eric Thijl Vanstreels, Ricardo L. Palma, Sergey V. Mironov
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
(Goethe University Frankfurt) A newly developed video technique has allowed scientists at Goethe University Frankfurt at the Bee Research Institute of the Polytechnical Society to record the complete development of a honey bee in its hive. Researchers discovered that certain pesticides -- neonicotinoids -- changed the behaviour of the nurse bees: they fed the larvae less often. Larval development took up to 10 hours longer. A longer development period in the hive can foster infestation by parasites.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
This week's interesting case was donated by Drs. Lee Decollings and Dejan Nikolic. The patient is a middle-aged male with travel approximately 2 months ago to Ethiopia, Nigeria and Cameroon. In the past few years, he has also traveled broadly in sub-Saharan Africa, Asia and South America. He presented with fever and myalgias following a recent medical procedure.Diagnosis? Where did he likely acquire this infection?
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Bacteriophages are bacterial parasites and are considered the most abundant and diverse biological entities on the planet. Previously we identified 154 prophages from 151 serovars of Salmonella enterica subsp. en...
Source: BMC Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
Intestinal protozoa are responsible for relatively few infections in the developed world, but the testing volume is disproportionately high. Manual light microscopy of stool remains the gold standard but can be insensitive, time-consuming, and difficult to maintain competency. Artificial intelligence and digital slide scanning show promise for revolutionizing the clinical parasitology laboratory by augmenting the detection of parasites and slide interpretation using a convolutional neural network (CNN) model. The goal of this study was to develop a sensitive model that could screen out negative trichrome slides, while flag...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Parasitology Source Type: research
by Esra Yilmaz, Moritz Fritzenw.er, Nikola Pantchev, Mathias Lendner, Sirichit Wongkamchai, Domenico Otranto, Inge Kroidl, Martin Dennebaum, Thanh Hoa Le, Tran Anh Le, Sabrina Ram ünke, Roland Schaper, Georg von Samson-Himmelstjerna, Sven Poppert, Jürgen Krücken
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
by Jayden Logan, Mark S. Pearson, Srikanth S. Manda, Young-Jun Choi, Matthew Field, Ramon M. Eichenberger, Jason Mulvenna, Shivashankar H. Nagaraj, Ricardo T. Fujiwara, Pedro Gazzinelli-Guimaraes, Lilian Bueno, Vitor Mati, Jeffrey M. Bethony, Makedonka Mitreva, Javier Sotillo, Alex Loukas The human hookwormNecator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stageN.americanus live in the small intestine of the human host where they inject excretory/secretory (ES) products into the mucosa. ES products have been characterized at the proteome lev...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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