The Era of Thromboinflammation: Platelets Are Dynamic Sensors and Effector Cells During Infectious Diseases

Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of literature supports the evolving role of platelets as key sentinel and effector cells in infectious diseases, especially critical in bridging hemostatic, inflammatory, and immune continuums. Upon intravascular pathogen invasion, platelets can directly sense viral, parasitic, and bacterial infections through pattern recognition receptors and integrin receptors or pathogen: immunoglobulin complexes through Fc and complement receptors—although our understanding of these interactions remains incomplete. Constantly scanning for areas of injury or inflammation as they circulate in the vasculature, platelets also indirectly respond to pathogen invasion through interactions with leukocytes and the endothelium. Following antigen recognition, platelets often become activated. Through a diverse repertoire of mechanisms, activated platelets can directly sequester or kill pathogens, or facilitate pathogen clearance by activating macrophages and neutrophils, promoting neutrophil extracellular traps (NETs) formation, forming platelet aggregates and microthrombi. At times, however, platelet activation may also be injurious to the host, exacerbating inflammation and promoting endothelial damage and thrombosis. There are many gaps in our understandings of the role of platelets in infectious diseases. However, with the emergence of advanced technologies, our knowledge is increasing. In the current ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Authors: Günal A, Pekçetin S, Demirtürk F, ┼×enol H, Håkansson C, Wagman P Abstract Background: Occupational balance (OB) is an important concept in occupational therapy and is considered as an essential component of health and well-being. Aim: The aim of this study was to investigate the validity and reliability of the Turkish version of the Occupational Balance Questionnaire-11 (OBQ11-T). Materials and methods: The OBQ11-T was administered to 116 individuals for construct validity analysis and to 58 individuals for reliability analysis. Validity was determined using explanatory and confirma...
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Conclusion: MDCT provides good results in detecting sinus fat, venous invasion and kidney-confined tumors, but evaluation of perinephric fat remains a difficult task, leading to reduced accuracy in T3a staging. PMID: 31607203 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
This study was aimed to estimate the length of the MIC in the interforaminal safe zone, to analyse its course in relation to the lingual and the buccal cortical plates of the mandible using cone beam computed tomography (CBCT) scans and to relate the above findings to age, gender, dental status and Malaysian races.MethodsRetrospective analysis of 100 CBCT scans (n = 200) was performed on both sides of the mandible. Cross-sectional and panoramic images were reconstructed. The length of the MIC and the horizontal distances between the MIC and the buccal and the lingual cortical plates were measured at the three...
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
Background From infancy to adulthood, the mandible develops increased ramus height, prominence of the chin, and laterally widened gonial angles. In Crouzon and Apert syndromes, both relative retrognathia and prognathic jaws have been reported. Growth is influenced by a variety of factors, including the growth and relative position of the skull base, functional coordination, and the spatial influence of the laryngopharynx. Thus, this study aimed to explore in detail the evolution of the mandible in both syndromes and its relationship with the entire facial structure and skull base. Methods One hundred twenty-three preo...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Research Source Type: research
In this issue, Tang et al. [1] from Taiwan report on an increasingly important issue in thoracic medicine and surgery, the natural history of small, asymptomatic lung nodules. The widespread use, over the last couple of decades, of increasingly sensitive computed tomography (CT) scans with reducing radiation dose has resulted in the recognition of a significant population of otherwise healthy patients who have a lung nodule of undefined nature. In most cases, this lung nodule has been detected at the time of a CT scan for a completely different issue —atypical chest pain, back pain, shoulder pain, and often for inves...
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Editorial Source Type: research
Publication date: Available online 14 October 2019Source: Materials Today CommunicationsAuthor(s): Marzie Farjami, Vahid Vatanpour, Abdolreza MoghadassiAbstractThe influence of various additives of PEG (with MW = 1000, 4000 g/mol), PVP (with MW = 10000, 29000 g/mol) and Pluronic F-17 on the attributes and performance of the EPVC and EPVC/boehmite nanocomposite membranes was studied. Water contact angle, scanning electron microscopy (SEM), atomic force microscopy (AFM) and energy dispersive X-ray (EDX) analyses and also the obtained results of pure water flux, bovine serum albumin (...
Source: Materials Today Communications - Category: Materials Science Source Type: research
Publication date: Available online 14 October 2019Source: Physics Letters BAuthor(s): He Liu, Feng-Tao Wang, Kai-Jia Sun, Jun Xu, Che Ming KoAbstractBased on the framework of an extended multiphase transport model with mean-field potentials in both the partonic phase and the hadronic phase, we explain the elliptic flow difference between π+ and π− in the beam-energy scan program at the relativistic heavy-ion collider by incorporating the vector-isovector potential for quarks and antiquarks with different isospins. It is found that the isospin splitting of pion elliptic flow favors a strong vector-isovector inte...
Source: Physics Letters B - Category: Physics Source Type: research
Authors: Bader MS, Loeb M, Leto D, Brooks AA Abstract Urinary tract infections (UTIs) caused by antibiotic- resistant Gram-negative bacteria are a growing concern due to limited treatment options. Knowledge of the common uropathogens in addition to local susceptibility patterns is essential in determining appropriate empiric antibiotic therapy of UTIs. The recommended first-line empiric antibiotic therapy for acute uncomplicated bacterial cystitis in otherwise healthy adult nonpregnant females is a 5-day course of nitrofurantion, a 3-g single dose of fosfomycin tromethamine, or a 5-day course of pevmecillinam. High...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Publication date: 5 February 2020Source: Journal of Molecular Structure, Volume 1201Author(s): Mohammad Asad, Muhammad Nadeem Arshad, Salman A. Khan, Mohammad Oves, Muhammad Khalid, Abdullah M. Asiri, Ataualpa A.C. BragaAbstractThe chalcones have been cyclized into the N-propionyl-2-pyrazolines using propionic acid with hydrazine hydrate. The structures of pyrazolines were determined by FT-IR, NMR spectroscopy, and confirmed by single crystal X-ray diffraction (SC-XRD) study. Further, a combined experimental and density functional theory (DFT) based study of these pyrazolines has been reported. A comprehensive DFT investig...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 15 October 2019Source: Journal of Bioscience and BioengineeringAuthor(s): Shaun N. Robertson, Peter G. Childs, Ayorinde Akinbobola, Fiona L. Henriquez, Gordon Ramage, Stuart Reid, William G. Mackay, Craig WilliamsBacterial biofilms pose a significant burden in both healthcare and industrial environments. With the limited effectiveness of current biofilm control strategies, novel or adjunctive methods in biofilm control are being actively pursued. Reported here, is the first evidence of the application of nanovibrational stimulation (nanokicking) to reduce the biofilm formation of Pseudomo...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
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