Smooth muscle cell phenotypic diversity between dissected and unaffected thoracic aortic media.

Conclusion: We have established a simple and potent method to acquire SMCs from the dissected and unaffected aortic media. Compared to the contractile SMCs in the unaffected media, those in the dissected media manifest phenotypic switching from the contractile to the synthetic type. The primary cultures can be subsequently used as in vitro models and contribute to further elucidating the etiopathogenesis of TAD.
PMID: 23594508 [PubMed - as supplied by publisher]

Source: The Journal of Cardiovascular Surgery - April 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Zhang J, Wang L, Fu W, Wang C, Guo D, Jiang J, Wang Y Tags: J Cardiovasc Surg (Torino) Source Type: research