Evaluating the performance of a predictive modeling approach to identifying members at high-risk of hospitalization.

Conclusions: The predictability of the Blue Cross models show how member-specific, regional data can be used to accurately identify patients with a high ROH, which may allow healthcare workers to intervene earlier and subsequently reduce the healthcare burden for patients and providers. PMID: 31505982 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research

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Host Kevin Patton summarizes the 2019 Nobel Prize in Physiology or Medicine to three scientists "for their discoveries of how cells sense and adapt to oxygen availability." A special bonus episode.00:41 | Introduction to Bonus Episode02:00 | Sponsored by HAPS02:24 | Summary of Discovery04:13 | Oxygen at Center Stage05:24 | HIF Enters the Scene08:08 | Sponsored by AAA08:26 | VHL - An Unexpected Partner11:37 | Oxygen sHIFts the Balance13:20 | Oxygen Shapes Physiology&Pathology15:15 | Sponsored by HAPI Online Graduate Program15:48 | Our Course23:46 | Staying ConnectedIf you cannot see or...
Source: The A and P Professor - Category: Physiology Authors: Source Type: blogs
This study summarizes our 35-year experience in breast cancer (BC) in renal transplant patients focusing on the incidence of BC and its impact on survival of this population.MethodsProspectively collected data of female patients treated with renal transplantation for chronic renal failure from 1973 to 2017 were analysed. Patients diagnosed with BC were identified. Age at transplantation, age at BC diagnosis, date and causes of death were recorded for all patients. BC incidence and overall survival were calculated. Kaplan-Meier and Cox proportional hazards models were used to determine the difference in survival and hazard ...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
CONCLUSIONS: A novel, evidence-based decision aid was created for patients with renal masses considering surgery. The decision aid is available at https://decisionaid.ohri.ca/AZsumm.php?ID=1913. A separate decision aid addressing the management of small renal masses is currently under development. PMID: 31540831 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
SummaryOsimertinib is a key drug for cancer patients withEGFR mutations. However, there is little information about its safety in cancer patients who require hemodialysis (HD) for chronic renal failure, despite notable increases in their numbers. Herein, we examined osimertinib safety in such a patient via pharmacokinetics analysis. A 66-year-old man was diagnosed with relapsed stage IV non-small cell lung cancer with anEGFR mutation in exon 21 (L858R) 2  years after stereotactic body radiotherapy. He was undergoing HD three times a week owing to worsening diabetic nephropathy. We administered osimertinib (80 mg/...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
The regulatory pathway for Shockwave Medical’s Intravascular Lithotripsy (IVL) technology just received a huge jolt from FDA. The agency granted the Santa Clara, CA-based company breakthrough device designation for the Shockwave IVL System with the Shockwave C2 Coronary IVL Catheter. The firm’s device is designed to fracture problematic calcium using sonic pressure to facilitate stent delivery, deployment, and optimal expansion, thereby improving blood flow to the heart muscle. Shockwave’s technology is being evaluated in the DISRUPT CAD III, a prospective, non-randomiz...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Cardiovascular Source Type: news
The decision as to whether patients should be admitted to a medical intensive care unit (ICU), in the absence of information concerning survival rates or prognostic factors in survival, is often challenging. We analyzed survival trends in relation to hospital discharge and examined patient and hospital characteristics associated with survival following ICU care, using a sample of nationwide claims data in Korea from 2002 through 2013. The Korean government implements a compulsory social insurance program that covers the country's entire population, and the Korean National Health Insurance Service-National Sample Cohort (NH...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
ConclusionsIn the Society of Thoracic Surgery database, 64% of patients suffer postoperative events and 3.3% die following esophagectomy. The independent association of certain postoperative events with mortality is an objective method of terming a complication “major” and may aid efforts to reduce mortality.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
ConclusionMachine learning was used to develop an algorithm that accurately predicted patient risk of developing complications following liver, pancreatic, or colorectal surgery. The algorithm had very  good predictive ability to predict specific complications and demonstrated superiority over other established methods.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
ConclusionSurgical treatment should be considered for pancreatic metastasis from lung cancer if the disease is localized and the patient’s condition is good. Additionally, combined therapy, including surgical resection, may be effective for repeated recurrence.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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