E3 ligase MDM2 mediates urea transporter A1 ubiquitination under either constitutive or stimulatory conditions.

In conclusion, MDM2 binds with UT-A1 and mediates its ubiquitination and degradation in an AP50 dependent manner, and their binding capacity is strengthened under FSK and diabetic milieu.
PMID: 31509007 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Renal Physiology - September 10, 2019 Category: Physiology Authors: Su H, Ye C, Sands JM, Zhang C Tags: Am J Physiol Renal Physiol Source Type: research