Regulation of mitochondria function by natriuretic peptides.

Regulation of mitochondria function by natriuretic peptides.
Am J Physiol Renal Physiol. 2019 Sep 11;:
Authors: Domondon M, Nikiforova AB, DeLeon-Pennell KY, Ilatovskaya DV
Abstract
Natriuretic peptides (NP) are well known to promote renal sodium excretion, opposing the effects caused by the renin-angiotensin-aldosterone system. Thus, NPs serve as a key component in the maintenance of the blood pressure, influencing fluid retention capabilities via osmoregulation. Recently, NPs have been shown to affect lipolysis, and enhance lipid oxidation and mitochondrial respiration. Here we provided an overview of current knowledge about the relationship between NPs and mitochondria-mediated processes such as reactive oxygen species production, calcium signaling, and apoptosis. Establishing a clear physiological and mechanistic connection between NPs and mitochondria in the cardiovascular system will open new avenues of research aimed to understand and potentially utilize it as a therapeutic target from a completely new angle.
PMID: 31509010 [PubMed - as supplied by publisher]

Source: American Journal of Physiology. Renal Physiology - September 10, 2019 Category: Physiology Authors: Domondon M, Nikiforova AB, DeLeon-Pennell KY, Ilatovskaya DV Tags: Am J Physiol Renal Physiol Source Type: research