Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses.

CONCLUSION: This is the first study to demonstrate that RvD1 effects on the reduction of pro-inflammatory responses in LPS-induced microglial cells. The mechanisms underlying these effects may include its potent intracellular NF-κB down-regulation and subsequent pro-inflammatory cytokines release in LPS-activated microglia. PMID: 23521911 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/23521911?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - April 1, 2013 Category: Neuroscience Authors: Xu MX, Tan BC, Zhou W, Wei T, Lai WH, Tan JW, Dong JH Tags: CNS Neurosci Ther Source Type: research