Vitamin D3 induces IDO(+) tolerogenic DCs and enhances Treg, reducing the severity of EAE.

CONCLUSION: These mechanisms contribute actively to the generation of a microenvironment in the lymph nodes that suppresses the activation of encephalitogenic T cells, resulting in the downregulation of the inflammatory response in the central nervous system.
PMID: 23521914 [PubMed - in process]

Source: CNS Neuroscience and Therapeutics - April 1, 2013 Category: Neuroscience Authors: Farias AS, Spagnol GS, Bordeaux-Rego P, Oliveira CO, Fontana AG, de Paula RF, Santos MP, Pradella F, Moraes AS, Oliveira EC, Longhini AL, Rezende AC, Vaisberg MW, Santos LM Tags: CNS Neurosci Ther Source Type: research