Zinc Promotes the Death of Hypoxic Astrocytes by Upregulating Hypoxia-Induced Hypoxia-Inducible Factor-1alpha Expression via Poly(ADP-ribose) Polymerase-1.

CONCLUSIONS: Our studies show that zinc promotes hypoxic cell death through overexpression of the hypoxia response factor HIF-1α via the cell fate determine factor PARP-1 modification, which provides a novel mechanism for zinc-mediated ischemic brain injury. PMID: 23582235 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23582235?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - April 13, 2013 Category: Neuroscience Authors: Pan R, Chen C, Liu WL, Liu KJ Tags: CNS Neurosci Ther Source Type: research