FDA OKs Tenapanor for IBS With Constipation in Adults FDA OKs Tenapanor for IBS With Constipation in Adults

Two phase 3 trials demonstrated a statistically significant reduction in constipation and abdominal pain in adults with IBS-C treated with tenapanor.FDA Approvals
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Gastroenterology News Alert Source Type: news

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Conclusions Prevalence of abdominal pain and constipation is high and increased after one year. Negative perception of school toilets with consecutive avoidance behavior could be an important and improvable influence. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Klinische Padiatrie - Category: Pediatrics Authors: Tags: Original Article Source Type: research
This study analyzed QoL data from a prospective multicenter patient-reported outcome registry in patients with pancreatic or periampullary carcinoma registered in the nationwide Netherlands Cancer Registry (2015-2018). Baseline and delta QoL, between baseline and 3-month follow-up, were assessed with the Happiness, EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), and QLQ-PAN26 questionnaires. The relationship between QoL and survival was assessed using Cox regression models, and additional prognostic value of separate items was assessed using Nagelkerke R2 (explained variance). RESULTS: For the baseline and delta...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Conclusion: POC is an extraordinarily rare disease, and commonly with a satisfactory outcome. TAH+BSO with or without postoperative chemotherapy has been considered as an acceptable treatment strategy for POC patients.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
A 19-year-old man with no significant past medical history presented to the emergency department for symptoms of fevers, cough, abdominal pain, nausea, and vomiting. He reported having cyclical fevers up to 103 °F for the past week. Four days before presentation, he developed nonlocalized abdominal pain and episodes of nonbloody emesis, not associated with any specific foods. He did not have diarrhea or constipation, and was passing flatus. He also developed a dry cough. Emesis was not associated with cou ghing fits.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents ’ clinic Source Type: research
We describe how to take a detailed history, perform meticulous digital rectal examination, and use validated tools to supplement clinical evaluation, including assessments of quality of life and scoring systems for disease severity and digital Apps. These tools could facilitate a comprehensive plan for clinical management including diagnostic tests, and translate the patients' complaints into definable, diagnostic categories. PMID: 32989182 [PubMed]
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
The opioid epidemic has plagued the United States with high levels of abuse and poor quality of life for chronic pain patients requiring continuous use of opioids. New drug discovery efforts have been implemented to mitigate this epidemic; however, new medications are still limited by low efficacy and/or high side effect and abuse potential. Intermittent fasting (IF) has recently been shown to improve a variety of pathological states, including stroke and neuroinflammation. Numerous animal and human studies have shown the benefits of IF in these disease states, but not in pain and opioid treatment. We thus subjected male a...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
When you take your car to Meineke, chances are you will get a muffler. Well, it seems when you take children to the emergency department or an urgent care center for abdominal pain due to constipation, chances are they will get an abdominal x-ray (AXR). Children discharged with a diagnosis of constipation account for up to 25% of cases seen in some emergency departments or urgent care centers, and as many as 30%-90% will have an AXR as part of their evaluation. Evidenced-based guidelines for the “Evaluation and Treatment of Functional Constipation in Infants and Children” published jointly by the North American...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
Objectives: Clinical features of eosinophilic esophagitis (EoE) have been well-described in the literature, however, characterization of features experienced by patients with other eosinophilic gastrointestinal diseases (EGIDs) is lacking. Using data collected from a patient contact registry, we sought to characterize and contrast patient-reported gastrointestinal and extragastrointestinal symptoms and comorbidities in non-EoE EGIDs, including eosinophilic gastritis, gastroenteritis and colitis, relative to EoE. Methods: We conducted a cross-sectional study of contact registry data collected from 2015 to 2018. Statist...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Article: Gastroenterology: Eosinophilic Gastrointestinal GI Disease Source Type: research
Raquel Abalo Mast cells are key actors in inflammatory reactions. Upon activation, they release histamine, heparin and nerve growth factor, among many other mediators that modulate immune response and neuron sensitization. One important feature of mast cells is that their population is usually increased in animal models and biopsies from patients with irritable bowel syndrome (IBS). Therefore, mast cells and mast cell mediators are regarded as key components in IBS pathophysiology. IBS is a common functional gastrointestinal disorder affecting the quality of life of up to 20% of the population worldwide. It is chara...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Conclusion: Laparoscopic surgery with NOSE for eligible patients with CRC was a feasible choice. PMID: 32940092 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
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