Insights From 2 Outbreaks in Southeastern Brazil

In recent years, public health threats due to Zika virus (ZIKV) and Ebola virus have increased awareness among the ophthalmic community regarding the visual effect of ocular sequelae identified in association with these emerging infectious diseases. Yellow fever virus (YFV), deemed the “original viral hemorrhagic fever,” resides in the Flavivirus family, which includes other mosquito-borne illnesses, including Dengue (DENV), West Nile (WNV), and ZIKV. Forty-seven countries in Africa (34 [72.3%]) and Central and South America (13 [27.7%]) are endemic for, or have regions endemi c for, YFV, underscoring its global health significance. Within Brazil, a seasonal pattern of infectivity is observed from December to May. During the 2017 to 2018 yellow fever (YF) season, 1376 people with YF and 483 deaths were reported.
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research

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Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: REVIEW ARTICLE Source Type: research
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In this study, we evaluated ATA as a potential antiviral drug against ZIKV replication. The antiviral activity of ATA against ZIKV replication in vitro showed median inhibitory concentrations (IC50) of 13.87 ± 1.09 μM and 33.33 ± 1.13 μM in Vero and A549 cells, respectively; without showing any cytotoxic effect in both cell lines (median cytotoxic concentration (CC50)> 1,000 μM). Moreover, ATA protected both cell types from ZIKV-induced cytopathic effect (CPE) and apoptosis in a time- and concentration-dependent manner. In addition, pre-treatment of Vero cells with ATA for up to 72 h also resulted...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Science - The Huffington Post - Category: Science Source Type: news
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