Only pathogenic variants in protein-coding mtDNA genes cause Leigh syndrome

With interest we read the article by Mani et al. about 165 patients with thiamin-responsive Leigh syndrome in whom 100 non-synonymous mtDNA variants in protein-coding mtDNA genes were detected [1]. We have the following comments and concerns.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research