Selective head cooling and whole body cooling as neuroprotective agents in severe perinatal asphyxia

CONCLUSIONS Both methods demonstrated to have neuroprotective properties, although full-body cooling provides a broader area of protection. Recently, head cooling combined with some body cooling has been applied, which is the most promising approach. The challenge for the future is to find ways of improving the effectiveness of the treatment.RESUMO INTRODU ÇÃO A possibilidade de a hipotermia ter um papel terapêutico durante ou após a reanimação da asfixia perinatal grave tem sido um foco de pesquisa de longa data. Estudos desenhados em torno desse fato mostraram que a hipotermia cerebral moderada, iniciada o mais cedo possível, tem sido associ ada à neuroproteção potente e duradoura em espécies perinatais. OBJETIVOS Resumidamente, analisar os benefícios da hipotermia na melhoria da função celular, com base nas características celulares da lesão cerebral hipóxico-isquêmica e comparar os resultados de dois métodos diferentes de resfriamento do parênquima cerebral. MATERIAL E MÉTODOS Medline, Lilacs, SciELO e PubMed foram pesquisados para artigos registrados entre 1990 e 2019 nos idiomas português e inglês, com foco em estudos comparando segurança e eficácia do resfriamento corporal total com o resfriamento seletivo da cabeça com EHI. RESULTADOS Descobrimos que o resfriamento de corpo inteiro fornece resf...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research

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Publication date: Available online 18 October 2019Source: Journal of Neonatal NursingAuthor(s): Miriam Langan, C. Watson, T. O'Connor, Z. Moore, D. PattonAbstractHypothermia is strongly associated with neonatal morbidities and mortality. There are several interventions to reduce the incidence of hypothermia following delivery. The aim of this systematic review was to compare the effectiveness of combining warming mattresses and plastic bags to plastic bags only for thermal regulation in preterm infants in the delivery suite and during stabilisation in the NICU. Four studies met the inclusion criteria. In comparison to the ...
Source: Journal of Neonatal Nursing - Category: Perinatology & Neonatology Source Type: research
Condition:   Inadvertent Perioperative Hypothermia Intervention:   Procedure: convective active warming Sponsors:   St. Marien-Hospital Düren;   Institute for Occupational, Social and Environmental Medicine, RWTH Aachen University;   Department of Anaesthesiology and Intensive Care Medicine, Hospital Düren Active, not recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Zhang FJ, Song HQ, Li XM Abstract The aim of the present study was to investigate the effect of ulinastatin (UTI) alone or combined with mild therapeutic hypothermia (MTH) on intestinal barrier dysfunction following cardiopulmonary resuscitation (CPR) in rats. A total of 25 adult male Sprague-Dawley rats were randomly organized into five groups: Sham; control; UTI; MTH; and the combined group. The latter four groups were induced with the asphyxiated cardiac arrest rat model and treated with different interventions. After 6 h of treatment, the intestinal tissues of the rats were examined by electron microsc...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
More patients in arrest with nonshockable rhythms survived with favorable neurologic outcomes if they received moderate therapeutic hypothermia rather than targeted normothermia in a randomized trial.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news
Journal of Perinatology, Published online: 15 October 2019; doi:10.1038/s41372-019-0533-4Opioid and benzodiazepine use during therapeutic hypothermia in encephalopathic neonates
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
Source: Journal of Maternal-Fetal and Neonatal Medicine - Category: Perinatology & Neonatology Authors: Source Type: research
(Natural News) Hypothermia is a deadly condition that develops in cold temperatures. Preppers must know how to prevent it from happening in the first place – and how to treat it. When a person’s core body temperature drops below 95 F (35 C), he undergoes hypothermia. Dehydration and starvation increase the risk of the condition....
Source: - Category: Consumer Health News Source Type: news
Conclusions: Phosphorylated hexa-acyl disaccharides significantly augment resistance against clinically relevant Gram-negative and Gram-positive infections via enhanced leukocyte recruitment, phagocytosis, and respiratory burst functions of innate leukocytes. Improved antimicrobial protection persists for up to 10 days and is partially mediated through toll-like receptor 4.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research
This study was designed to investigate the effect of an acute intraperitoneal (i.p.) administration of JWH-018-R compounds (0.01-6 mg/kg) on sensorimotor functions in mice and to compare them to those caused by the reference compound JWH-018 and Δ9-THC. A well validated battery of behavioral tests was used to investigate the effects of these synthetic cannabinoids on the visual, auditory and tactile responses in mice, while the pre-pulse inhibition (PPI) test was used to investigate their effect on sensorimotor gating. The effect of the synthetic cannabinoids on spontaneous locomotion was also measured by a vi...
Source: Neurotoxicology - Category: Neurology Authors: Tags: Neurotoxicology Source Type: research
Publication date: Available online 8 October 2019Source: Journal of the Saudi Heart AssociationAuthor(s): Jayavelan Ramkumar, Girish Gopinathan, Karthick Kavin, Ramkumar Shanmugasundaram, George Miller Stephen, Annie Caroline Pragasam, Periyasamy ThangavelAbstractAims and objectiveThe primary objective was to study the effects of cardiopulmonary bypass (CPB) perfusion temperature on renal function parameters (Serum creatinine, Creatinine clearance, Urine Albumin, Urine Protein and Urine Albumin Creatinine Ratio).The secondary objective was to detect renal complications of CPB.Materials and MethodsIt is a prospective longit...
Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
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