The Heart Matters: Contribution of Genetic Factors in Recurrent Pericarditis.

The Heart Matters: Contribution of Genetic Factors in Recurrent Pericarditis. Isr Med Assoc J. 2019 Jul;21(7):487-490 Authors: Perricone C, Katz D, Ciccacci C, Ceccarelli F, Valesini G, Shoenfeld Y, Borgiani P, Conti F Abstract BACKGROUND: Recurrent pericarditis is a state of repetitive inflammation of the pericardium with intervals of remission. The etiology of recurrent pericarditis is still largely unknown, yet most causes are presumed to be immune mediated. Genetic factors, including human leukocyte antigen (HLA) haplotypes, can be involved in dysregulation of the immune system and as a predisposition to several autoimmune conditions, including recurrent pericarditis. Several diseases are frequently associated with such manifestations. They include systemic lupus erythematosus, familial Mediterranean fever, and tumor necrosis factor receptor-associated periodic syndrome. However, idiopathic recurrent pericarditis remains the most frequently observed clinical condition and the conundrum of this disease still needs to be solved. PMID: 31507126 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research