Obesity Impairs Efficacy of L-Asparaginase in Leukemia Treatment

Findings suggesting that obesity substantially impairs the ability of L-asparaginase to kill leukemia cells were reported last month by investigators from The Saban Research Institute, Children’s Hospital Los Angeles.
Source: Cancer Network - Category: Cancer & Oncology Source Type: news

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Source: Clinical Nutrition - Category: Nutrition Authors: Tags: Nutritional techniques and formulations/Obesity and the metabolic syndrome/Nutrition and cancer/Nutritional assessment Source Type: research
MONDAY, Aug. 5, 2019 -- For Mexican children with acute lymphoblastic leukemia (ALL), overweight and obesity are predictors of early mortality, according to a study published online July 18 in BMC Cancer. Juan Carlos N úñez-Enríquez, M.D., from...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Infants born to obese mothers are more likely to develop childhood cancer, especially leukemia.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Conclusions: In summary, LBM selectively stratifies males and rVFA selectively stratifies females with DLBCL. There are robust male-specific effects of chemotherapy on tumor metabolism and patient survival, as identified with delta SULmax. Sex differences in tumor and patient metabolism can be used to better predict outcomes and response to therapy.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lymphoma / Leukemia Source Type: research
We examined whether birth certificate-derived maternal anthropometric characteristics are associated with increased risk of subsequent childhood cancer development, accounting for established maternal and infant risk factors. Pennsylvania birth and cancer registry files were linked by the state Department of Health, yielding a virtual cohort of births and childhood cancers from 2003 through 2016. The analysis included 1,827,875 infants (13,785,309 person-years at risk), with 2,352 children diagnosed with any cancer and 747 with leukemia before age 14. Children born to mothers with a body mass index ≥40 kg/m2 had 57% (12...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
Publication date: Available online 16 May 2019Source: Trends in Food Science &TechnologyAuthor(s): Andrzej Sidor, Agnieszka Drożdżyńska, Anna Gramza-MichałowskaAbstractBackgroundBlack chokeberry fruits (Aronia melnocarpa) are used in the food industry for the production of juices, preserves, tinctures, fruit teas and dietary supplements. Fresh, unprocessed black chokeberry fruits however are rarely consumed due to their bitter taste, resulting from the presence of a significant amount of polyphenols. Polyphenols are biofactors that determine the high activity of black chokeberries, including proanthocyanidins, anth...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Introduction The late effects of radiation therapy can have significant consequences for the health and quality of life of long-term cancer survivors. Radiation induces persistent alterations in hematopoietic stem and progenitor cells (HSPC) and the bone marrow environment; however, how relevant host factors such as obesity and exercise differentially regulate HSPC content and the bone marrow environment after radiation exposure remains unknown. The purpose of this investigation was to evaluate how the combination of obesity and exercise training modulates HSPC and their niche after sublethal radiation exposure in mice. ...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: BASIC SCIENCES Source Type: research
Conclusion.Although paclitaxel‐induced neuropathy is common, older age is not an independent risk factor. Clinical trial identification number. NCT00041119 (CALGB 40101).Implications for Practice.Age alone is not an independent risk factor for paclitaxel‐induced neuropathy.
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Breast Cancer, Geriatric Oncology Source Type: research
ConclusionsWe recommend developing collaborative initiatives to build a regional repository of systematically assessed health outcomes and biospecimens to investigate treatment, social-environmental and genetic predictors, and interventions for late effects in this population.Implications for Cancer SurvivorsThe existing types of chronic health problems identified in this review suggest the need for active screening, better access to survivorship care, and promotion of protective health behavior in Asia.
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
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