This ‘Rose’ Has no Thorns—Diagnostic Utility of ‘Rapid On-Site Evaluation’ (ROSE) in Fine Needle Aspiration Cytology

AbstractFine needle aspiration (FNA) cytology is a basic diagnostic technique used  to investigate superficial and deep swellings. Rapid on-site evaluation (ROSE) using toluidine blue (TB) is easily available, cheap, cost-effective, can be used both for testing adequacy and giving provisional diagnosis. To evaluate the role of ROSE using toluidine blue staining in arriving at a diagnosis in comparison to routine stains. A total of 1500 cases of FNA of palpable swellings from sites like salivary gland, breast, thyroid, lymph node, and soft tissue lesions [non-image guided] during a 9-month period were studied. All the cases were evaluated by ROSE using toluidine blue sta in and routine Giemsa/PAP staining. The results were compared in each case. Only 2% cases proved inadequate on TB, Giemsa and PAP combination, commonest site of inadequacy being lymph node. Adequate sample was obtained within two passes in 92.5% cases. The turn-around time (TAT) was 1 day in 96.4% of cases. The average time for making a provisional diagnosis on TB was 3 minutes. There was 99.2% concordance between TB and final cyto-diagnosis. Validity parameters: sensitivity 98%, specificity 100%, positive predictive value 100%, negative predictive value 99.8%, efficacy 99.2% and false nega tive 1.94%. ROSE using toluidine blue is a reliable means of demonstrating sample adequacy, for making a provisional diagnosis and guiding collection of diagnostic material for microb...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research

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ConclusionsComparative analyses of molecular alterations in CNB compared to FNA showed high concordance in terms of variants as well as CNVs identified. FNA could therefore be easily used in routine diagnostics workflow and clinical trials for tumour molecular screening with the advantage of being minimally invasive.Clinical trial identificationNCT03084757 SHIVA02; Trial release date: April 1, 2017.Legal entity responsible for the studyInstitut Curie.FundingMSD Avenir Fundation.DisclosureC. Le Tourneau: Advisory / Consultancy: MSD, BMS, Merck Serono, AstraZeneca, Novartis, Roche, Nanobiotix. All other authors have declared...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Peri ‐implant fluid collections and/or masses on implant protocol breast MRI are rarely seen 24 months after surgery. Image‐guided fine needle aspiration of delayed peri‐implant fluid collection may be considered, as there is a significant association with breast implant associated anaplastic larg e cell lymphoma. AbstractBackgroundTo assess the incidence of benign and malignant peri ‐implant fluid collections and/or masses on magnetic resonance imaging (MRI) in women with silicone implants who are being screened for silent implant rupture.MethodsThe institutional review board approved this HIPAA ‐compliant ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune...
Source: Polish Journal of Pathology - Category: Pathology Tags: Pol J Pathol Source Type: research
ConclusionOur results showed that performing US of the axilla is not justified in screen detected breast cancer patients.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
CONCLUSION: FNAC is a simple, reliable, cost effective, first line diagnostic procedure for all breast lumps. In collaboration with physical examination and imaging studies (triple approach), FNAC is a highly sensitive diagnostic tool. Adopting a universally acceptable standardized reporting system for breast cytology can enhance the diagnostic accuracy of FNAC. PMID: 31524134 [PubMed - as supplied by publisher]
Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
Publication date: Available online 21 August 2019Source: Journal of the American Society of CytopathologyAuthor(s): Russel Fetzer, Michelle Duey, Valerie Pena, Dana Wanzer, James Kirkpatrick, Donnie Chau, Venetia R. SarodeAbstractIntroductionData on the performance of cytotechnologists in assessing specimen adequacy of needle core biopsies (NCB) is scant and their role in specimen triaging for ancillary studies have not been well established.Materials and methodsWe retrospectively analyzed ROSE performed exclusively by cytotechnologists on 248 NCB and fine needle aspiration (FNA) specimens. Overall adequacy and accuracy ra...
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
This study aimed to assess the potential of state-of-the-art ultrasound analysis techniques to non-invasively diagnose axillary lymph nodes involvement in breast cancer. After exclusion criteria, 105 patients were selected from two different hospitals. The 118 lymph node ultrasound images taken from these patients were divided into 53 cases and 65 controls, which made up the study series. The clinical outcome of each node was verified by ultrasound-guided fine needle aspiration, core needle biopsy or surgical biopsy.
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Tags: Original Contribution Source Type: research
CONCLUSIONS: Second-look US using anatomical breast structures as indicators and US-guided FNAC are useful for refining the diagnosis of suspicious breast lesions detected using MRI. PMID: 31407151 [PubMed - as supplied by publisher]
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
Publication date: Available online 9 August 2019Source: IDCasesAuthor(s): Ashley Ceniceros, Benjamin Galen, Theresa MadalineAbstractA 32-year-old woman nonlactational woman with a nipple piercing and previous oral-to-breast contact presented with findings consistent with mastitis and abscess, however, the patient failed multiple courses of empiric antimicrobials. Needle aspiration was performed and the culture was positive for N. gonorrhoeae. She was successfully treated with intravenous ceftriaxone and transitioned to oral ciprofloxacin once susceptibilities were known.N. gonorrhoeae is an uncommon cause of nonlactational...
Source: IDCases - Category: Infectious Diseases Source Type: research
Direct exposure to 5 ‐aminolevulinic acid and Ko143 may be a promising strategy for efficient fluorescence detection of breast cancer cells ex vivo using fine needle aspiration. AbstractProtoporphyrin IX ‐fluorescence measurement is a powerful in situ approach for cancer detection after oral/topical administration of 5‐aminolevulinic acid. However, this approach has not been clinically established for breast cancer, probably due to insufficient delivery of 5‐aminolevulinic acid to the mammary glands. In the present study, we directly exposed breast cancer cells to 5‐aminolevulinic acid to assess their discriminat...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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