JAK inhibitors for the treatment of autoimmune and inflammatory diseases

Publication date: Available online 11 September 2019Source: Autoimmunity ReviewsAuthor(s): Yvan Jamilloux, Thomas El Jammal, Lucine Vuitton, Mathieu Gerfaud-Valentin, Sébastien Kerever, Pascal SèveAbstractCytokines play a central role in the pathophysiology of autoimmune and inflammatory diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized as a major target to inhibit the effect of a wide array of cytokines. JAK inhibitors are increasingly used in the setting of inflammatory and autoimmune diseases. While the currently approved drugs are panJAK inhibitors, more selective small molecules are being developed and tested in various rheumatic disorders. In this extensive review, we present evidence- or hypothesis-based perspectives for these drugs in various rheumatologic conditions, such as rheumatoid arthritis, systemic lupus erythematosus, giant cell arteritis, and autoinflammatory diseases.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research