IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression.

CONCLUSIONS: While having only a small impact on basal PD-L1 expression, both wildtype and mutated p53 play an important positive role for IFN-ɣ-induced PD-L1 expression in melanoma cells by supporting JAK2 expression. Future studies should address, whether p53 expression levels might influence response to anti-PD-1 immunotherapy.
PMID: 31506076 [PubMed - in process]

Source: Clin Med Res - September 10, 2019 Category: Research Authors: Thiem A, Hesbacher S, Kneitz H, di Primio T, Heppt MV, Hermanns HM, Goebeler M, Meierjohann S, Houben R, Schrama D Tags: J Exp Clin Cancer Res Source Type: research