Characterization of reemergent anti-B red blood cell antibodies in a patient with recurrent acute myeloid leukemia with ABO-incompatible allogeneic peripheral blood stem cell transplantation.

CONCLUSION: To our knowledge, this is the first report investigating the characteristic changes of isohemagglutinins between the pre- and post-HSCT sera in a patient with recurrent acute myeloid leukemia. The present study suggests that the plasma cells producing anti-donor B RBCs in the patient have been selectively eliminated or induced into an anergic state by the post-HSCT immunologic reconstruction.
PMID: 31503348 [PubMed - as supplied by publisher]

Source: Transfusion - September 9, 2019 Category: Hematology Authors: Tajima K, Takizawa K, Yasuda T, Tsumanuma R, Okuyama S, Kumagai H, Omoto E, Okumura W Tags: Transfusion Source Type: research