Influence of hormones on the immunotolerogenic molecule HLA-G: a cross-sectional study in patients with congenital adrenal hyperplasia.

CONCLUSION: CAH patients had higher HLA-G levels than healthy controls. HLA-G level was positively associated with progesterone and corticosteroid supplementation, and negatively with estradiol. The association between mineralocorticoid, renin and HLA-G levels may suggest a role of the renin-angiotensin system in the expression of soluble HLA-G.
PMID: 31505456 [PubMed - as supplied by publisher]

Source: European Journal of Endocrinology - August 31, 2019 Category: Endocrinology Authors: Nguyen LS, Rouas-Freiss N, Funck-Brentano C, Leban M, Carosella E, Touraine P, Varnous S, Bachelot A, Salem JE Tags: Eur J Endocrinol Source Type: research