IGF-1 and IGF-1 SDS - fit for purpose?

IGF-1 and IGF-1 SDS - fit for purpose? Eur J Endocrinol. 2019 Sep 01;: Authors: Kos S, Cobbaert C, Kuijper MT, Oostdijk W, Hannema SE, Wit JM, Biermasz NR, Ballieux BE Abstract Three recent publications in this journal have reported that the differences in IGF-1 normative data significantly impact the classification of patients with growth hormone (GH)- excess and deficiency disorders in such a way that clinical performance is severely flawed. This concerns not only pediatric but also adult patients. With this letter, we aim to address additional issues, not previously addressed, which add to the complexity of the interpretation of IGF-1 results. Specifically, the relation between analytical performance of IGF-1 assays and acceptable clinical performance is discussed. PMID: 31505458 [PubMed - as supplied by publisher]
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research