Carvacrol Attenuates Diabetic Cardiomyopathy by Modulating the PI3K/AKT/GLUT4 Pathway in Diabetic Mice

Conclusion: Carvacrol protected against DCM in mice with T1DM and T2DM by restoring PI3K/AKT signaling-mediated GLUT4 membrane translocation and is a potential treatment of DCM.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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Conclusion: Septic patients with a past history of heart failure received 1L less IV fluids in the first 24 hours with no difference in mortality.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
RESUMO A sepse persiste como importante sobrecarga à saúde pública nos Estados Unidos e em todo o mundo. Com o crescente uso de tecnologias laboratoriais, tem se renovado o interesse na utilização de biomarcadores na sepse, para auxiliar em um processo mais preciso e direcionado para tomadas de decisão. Os peptídeos natriuréticos vem sendo c ada vez mais reconhecidos por seu papel que vai além da insuficiência cardíaca. Estes peptídeos estão comumente elevados em pacientes críticos que apresentam condições de disf...
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
To evaluate the risk of postoperative complications among diabetic and nondiabetic patients stratified by hemoglobin A1c (HbA1c).
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Virtual Poster Session 2: Basic Science/Research/Education (1:20 PM – 1:30 PM) 1:20 PM: STATION R Source Type: research
CONCLUSION: Our results did not identify a significantly different prevalence of altered and compatible PAD values in patients with HFpEF. However, we showed a prevalence of 19.4%, a high value if we consider similar populations.
Source: Clinics - Category: General Medicine Source Type: research
Alzheimer ’s disease (AD) is the most common neurodegenerative disease affecting the elderly worldwide. Mitochondrial dysfunction has been proposed as a key event in the etiology of AD. We have previously modeled amyloid-beta (Aβ)-induced mitochondrial dysfunction in a transgenicCaenorhabditis elegans strain by expressing human A β peptide specifically in neurons (GRU102). Here, we focus on the deeper metabolic changes associated with this Aβ-induced mitochondrial dysfunction. Integrating metabolomics, transcriptomics and computational modeling, we identify alterations in Tricarboxylic Acid (TCA) cycle...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
A new study from the University of Geneva, in Switzerland, found having a fatty liver might be another cause of type 2 diabetes because it can produce glucose on its own.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
For years, scientists assumed that mitochondria — the energy-generating centers of living cells — worked much like household batteries, generating energy from a chemical reaction inside a single chamber or cell. Now, UCLA researchers have shown that mitochondria are instead made up of many individual bioelectric units that generate energy in an array, similar to a Tesla electric car battery that packs thousands of battery cells to manage energy safely and provide fast access to very high current.“Nobody had looked at this before because we were so locked into this way of thinking; the assumption was that ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
This study sought to evaluate the effectiveness of PAP therapy for SDB on AF recurrence.Methods:This was a single-center, retrospective study conducted at a tertiary referral center. All adult patients who had SDB on polysomnography and underwent AF intervention (ablation or cardioversion) following polysomnography from January 1992-December 2014 were analyzed. Primary outcome was time to first-documented recurrence of AF after AF intervention by Kaplan–Meier estimates.Results:Among 30,188 patients with obstructive and central SDB, 429 had this diagnosis before AF intervention; 269 were“PAP-adherent users,&rdqu...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
In conclusion, on the basis of the current scientific research, it may be possible to formulate new therapies and achieve the appropriate selection of patients who can benefit from these therapies.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Conclusion Myocardial energy metabolism is a complex process, which consists of a network of biochemical reactions and pathways. The initial stage is energy substrate utilization due to its uptake and metabolism as well as following participation of intermediates in TCA cycle. Then mitochondrial oxidative phosphorylation enables generation of ATP molecules, and finally, the creatine kinase system transports ATP from mitochondria to the sarcomeres. In the light of the foregoing evidence, metabolism of the heart subjected to pressure overload may be disturbed in all of this areas. In spite of differences among humans and an...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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