Cancers, Vol. 11, Pages 1345: Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells

In conclusion, the data suggest that halting pro-survival autophagy by targeting PIK3C3 with MPT0L145 significantly sensitizes cancer cells to targeted or chemotherapeutic agents, fostering rational combination strategies for cancer therapy in the future.

Source: Cancers - September 10, 2019 Category: Cancer & Oncology Authors: Chun-Han Chen Tsung-Han Hsieh Yu-Chen Lin Yun-Ru Liu Jing-Ping Liou Yun Yen Tags: Article Source Type: research