Identification and Preservation of Arm Lymphatic System in Axillary Dissection for Breast Cancer to Reduce Arm Lymphedema Events: A Randomized Clinical Trial

This study aimed to examine the arm lymphedema rate, locoregional recurrence, and feasibility to perform DEPART in ALND.MethodsPatients from February 2013 to October 2017 from two tertiary referral centers were randomly assigned to two groups. In the study group, indocyanine green and methylene blue (MB) were utilized to identify arm sentinel nodes, and 0.1  ml MB was injected into the arm sentinel nodes to reveal the subsequent-echelon nodes and lymphatics. Gross arm lymph nodes were examined by intraoperative partial frozen section and were removed if positive. Arm lymphedema, local recurrence, regional recurrence, and distant metastasis were record ed at different follow-up examinations.ResultsArm sentinel nodes were identified in 573 (83.2%) patients. Subsequent-echelon nodes and lymphatics were visualized in 558 (97.4%) patients. Metastatic arm nodes were identified in 38 (6.8%) patients. The arm lymphedema rate was 3.3% (18/543) in the study group versus 15.3% (99/648) in the control group (p 
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research

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Conditions:   Breast Cancer;   Lymphedema Interventions:   Procedure: 14 sessions of manual lymphatic drainage technique;   Other: the health education Sponsors:   University of Castilla-La Mancha;   Castilla-La Mancha Health Service Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Our study has shown that nearly half of the survivors were suffering from at least one of the late effects.The intervention helped in improving the loss of bone mineral density, hypothyroidism, cardiac dysfunction and qualityof life in Breast cancer survivors. PMID: 31554363 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Conclusion: Hyperthermia and radiation provide good local control with a favorable side effect profile. Thermoradiotherapy may be offered to patients with recurrent breast cancer, including those with extensive volumes of disease. PMID: 31544546 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Authors: Mayrovitz HN, Arzanova E, Somarriba S, Eisa S Abstract Tissue dielectric constant (TDC) measurements are increasingly used as quantitative adjunctive tools to detect and assess lymphedema. Various factors affect measured TDC values that may impact clinical interpretations. Our goal was to investigate possible impacts of: 1) anterior vs. medial arm measures, 2) total body water (TBW%) and arm fat percentages (AF%), 3) measurement depth, and 4) skin firmness. In 40 healthy women (24.5±2.5 years), TDC was measured bilaterally on anterior forearm to 0.5, 1.5, 2.5, and 5.0 mm depths using a multiprobe de...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
Authors: Sanal-Toprak C, Ozsoy-Unubolo T, Bahar-Ozdemir Y, Akyuz G Abstract The aim of this study is to evaluate the efficacy of intermittent pneumatic compression (IPC) as a substitute for manual lymphatic drainage (MLD) in complete decongestive therapy (CDT) for treatment of advanced stages of breast cancer-related lymphedema. In this randomized, single-blind, controlled study, 46 patients with breast cancer-related lymphedema were divided into 2 groups. Both MLD with compression bandage (CB) group (n=24) and IPC with CB group (n=22) received treatment 3 days a week for 5 weeks. Home exercise program was also giv...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
Authors: Yoosefinejad AK, Hadadi M, Eslamloo P Abstract Lymphedema following surgical treatment for breast cancer can impair balance and predispose patients to falling. Fullerton Advanced Balance (FAB) Scale is a reliable and valid tool which can identify persons with different balance levels, but its responsiveness has not been investigated in patients with lymphedema secondary to breast surgery. Thirty women with stage 2 lymphedema secondary to breast cancer treatment received complex decongestive therapy (CDT) for 2 weeks as a routine treatment method. They were evaluated with FAB Scale and Timed Up and Go Test ...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
AbstractPurpose of ReviewThe axilla is the most common site for breast cancer nodal metastases. Aggressive management includes axillary lymph node dissection (ALND), radiotherapy, and systemic therapy, but carries the risks of lymphedema and “overtreatment”. We review the clinical trials that led to de-escalation of axillary management and their nuances that are often overlooked.Recent FindingsWith the rise of sentinel lymph node biopsy, several trials conclude that ALND can be omitted in specific populations. However, the subtleties in those trials, such as the role of chemotherapy and radiotherapy, have yet t...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
daño-Coy J Abstract OBJECTIVE: To determine the effectiveness of Kinesio taping compared to compression garments during maintenance phase of complex decongestive therapy for breast cancer-related lymphedema. DESIGN: Randomized, cross-over, controlled trial. SETTING: Outpatient tertiary-level hospital rehabilitation setting. SUBJECTS: Randomized sample of 30 women with breast cancer-related lymphedema. INTERVENTIONS: Participants received two interventions, Kinesio taping and compression garment, both lasting four weeks, whose order was randomized by blocks. A four-week washout period was...
Source: Clinical Rehabilitation - Category: Rehabilitation Authors: Tags: Clin Rehabil Source Type: research
Conditions:   Lymphedema;   Seroma;   Pain, Postoperative;   Pain, Chest Intervention:   Behavioral: Swimming Sponsors:   Ottawa Hospital Research Institute;   University of Ottawa;   Bruyere Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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