Identification of non –severe combined immune deficiency T-cell lymphopenia at newborn screening for severe combined immune deficiency

Severe combined immune deficiency (SCID) is the first primary immunodeficiency amenable to population-based newborn screening (NBS) and is now available in all 50 states and Puerto Rico. NBS for SCID uses real-time quantitative polymerase chain reaction to measure the number of copies of T-cell restriction excision circles (TRECs) in DNA from newborn dried blood spots and reliably detects severe T-cell lymphopenia (TCL) at birth. SCID is the primary condition detected using this assay. However, it is well known that many secondary conditions, with varying degrees of TCL, are identified through SCID NBS.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Perspective Source Type: research