Sleep and rheumatic diseases

Publication date: Available online 11 September 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Tobias Boeselt, Rembert Koczulla, Christoph Nell, Bjoern Beutel, Konrad Guenther, Werner Cassel, Olaf Hildebrandt, Ulrich Koehler, Johannes KroenigAbstractThis review article discusses various forms of sleep disorders associated with musculoskeletal diseases (MD). It presents the pathophysiology and interaction of sleep-related disorders and MD and summarizes clinical symptoms and therapies from a somnological perspective.BackgroundA large number of patients suffering from MD report fragmented sleep with poor overall sleep quality. Sleep disorders often lead to increased symptoms such as daytime fatigue, depression, or increased pain intensity. In contrast, the perception of pain worsens the quality of sleep.Sleep is a complex regulation of hormonal and neuromodulatory influences to maintain regenerative processes and signal processing. Furthermore, interleukins (e.g., IL-6 and TNFα), messenger substances, or inflammatory markers (e.g., CRP) may have a regulatory influence on sleep.TherapySleep disorders in MD can often be treated with behavioral therapies or drug approaches. Another and very important influence is physical activity. In combination with training, regular physical activity can lead, for instance, to improved sleep quality, endurance performance, and reduced inflammation values. The change of lifestyle with regard to activity and nutrition is an...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research