Role of IL-33/ST2 signaling pathway in systemic sclerosis and other fibrotic diseases.

Role of IL-33/ST2 signaling pathway in systemic sclerosis and other fibrotic diseases. Clin Exp Rheumatol. 2019 Sep 03; Authors: Xu D, Barbour M, Jiang HR, Mu R Abstract Systemic sclerosis (SSc) is a complex autoimmune disease characterised by fibrosis of the skin and multiple internal organs. Interleukin 33 (IL-33) has recently been investigated as a potential key player in the pathogenesis of SSc and other fibrotic diseases, owing to its effects on tissue fibrosis. Understanding how IL-33 is regulated and how it contributes to the development of fibrosis will be important to elucidate disease pathogenesis and may shed light on new areas for therapeutic development for patients. Here we discuss the recent research progress in our understanding of the role and the underlying mechanisms of IL-33/ST2 signaling pathway in SSc and other fibrotic diseases. PMID: 31498062 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research