Why are diabetes-related complications on the rise?
Diabetes has grown to become one of the most important public health concerns of our time. A review by the Harvard T.H. Chan School of Public Health has shown that the number of affected people has quadrupled in the last three decades. Type 2 diabetes (T2D), a type of diabetes traditionally occurring in adults and associated with obesity and a sedentary lifestyle, is now the ninth leading cause of death worldwide. It therefore comes as no surprise that this rapidly emerging epidemic is giving rise to a profusion of diabetes-related complications. What are the usual diabetes-related complications? As diabetes is a systemic disease, its effects are felt in virtually all parts of the body. Most diabetes-related complications are related to problems in the blood vessels, usually involving changes in blood flow or in the ability of blood to clot. These complications are generally classified into two broad categories: microvascular (involving small blood vessels) and macrovascular (involving large blood vessels). Microvascular damage is responsible for causing eye, kidney, and nerve complications, while macrovascular complications encompass stroke and heart disease and are currently the leading cause of diabetes-related death and disability. In some areas of the body, such as the lower extremities (legs and feet), as well as in wound healing, both small and large blood vessels may be involved. What are the trends in diabetes-related complication rates? A recent viewpoint article in...
CONCLUSIONS: The authors suggest stasis mucinosis and OALM represent the spectrum of euthyroid mucin depositional disease in varying clinical settings. PMID: 31730515 [PubMed - in process]
Authors: Bolton L Abstract Falls are the leading cause of injury, premature institutionalization, and long-term disability in elderly adults worldwide, with a fall-related fatality in the United States every 19 minutes.1 According to the Centers for Disease Control and Prevention,2 3 million people over 65 years of age receive emergency room treatment for fall injuries at an average cost of $30 000. The annual cost of fall injuries was more than $50 billion in 2015.1,2 Community-based interventions effective in preventing falls include exercise, medication, and nutritional management as well as improving safety of ...
CONCLUSIONS: This retrospective study further supports previous evidence that acellular fish skin graft promotes wound healing in DFUs. In particular, a rapid increase in wound healing was observed during the initial 4 weeks following graft application. This study and review of the literature indicated that fish graft encourages wound healing by enabling the wound to transition from a chronic to an acute stage of healing. PMID: 31730505 [PubMed - as supplied by publisher]
Learn all about how to detect type 1 diabetes in children and youth: signs, symptoms, and treatments.
Conclusions/interpretationThese results demonstrate a fundamental role for AIM2 in energy metabolism, inflammation and insulin resistance. Our studies establish a novel link between the innate immunity proteins, AIM2 and p202, and metabolism.
Conclusions/interpretationThis study provides a proof of principle for the use of iPSC-derived immune cells for modelling key cellular interactions in human type 1 diabetes.
Conclusions/interpretationOur results show a previously unappreciated role of adipocyteAtp7a in the regulation of ageing-related metabolic disease and identify new metallophysiologies in whole-body fat metabolism.Data availabilityThe datasets generated during the current study are available in the Genome Sequence Archive in BIG Data Center, Beijing Institute of Genomics (BIG), Chinese Academy of Sciences, under accession number CRA001769 (http://bigd.big.ac.cn/gsa).
Conclusions/interpretationShort-term structured strength and balance training did not influence HRQoL but produced sustained improvements in functional status and balance confidence at 6 months. More intensive interventions may be needed to influence HRQoL in these individuals. However, this intervention may be a useful treatment option for individuals with DPN to reduce the risk of falls and injuries.Trial registrationClinicalTrials.gov NCT02115932FundingThis work was supported by the National Medical Research Council, Singapore.
AbstractAims/hypothesisDiet is one of the main lifestyle-related factors that can modulate the inflammatory process. Surprisingly the dietary inflammatory index (DII) has been little investigated in relation to type 2 diabetes, and the role of BMI in this relationship is not well established. We studied this association and the role of BMI in the inflammatory process in a large population-based observational study.MethodsA total of 70,991 women from the E3N (Etude Epid émiologique auprès de femmes de la Mutuelle Générale de l’Education Nationale) cohort study were followed for 20 year...
AbstractAims/hypothesisCardiovascular disease is the most common comorbidity in type 1 diabetes. However, current guidelines do not include routine assessment of myocardial function. We investigated whether echocardiography provides incremental prognostic information in individuals with type 1 diabetes without known heart disease.MethodsA prospective cohort of individuals with type 1 diabetes without known heart disease was recruited from the outpatient clinic. Follow-up was performed through Danish national registers. The association of echocardiography with major adverse cardiovascular events (MACE) and the incremental p...
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