The effect of glutamatergic modulators on extracellular glutamate: How does this information contribute to the discovery of novel antidepressants?

ConclusionsThe strategy of using glutamatergic modulators as therapeutic agents requires a better understanding of the role of glutamate in the pathophysiology of depression. Gaining such understanding is a challenge because it entails evaluating different targets as well as the effects of these modulators on the kinetics of glutamate uptake. Essentially, glutamate transport is a dynamic process and, currently, it is still necessary to develop new approaches to assay glutamate in the synaptic cleft.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research