Multiple Roles of c-di-GMP Signaling in Bacterial Pathogenesis.

Multiple Roles of c-di-GMP Signaling in Bacterial Pathogenesis.
Annu Rev Microbiol. 2019 Sep 08;73:387-406
Authors: Valentini M, Filloux A
Abstract
The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of bacteria and controls many key functions and mechanisms. In the case of bacterial pathogens, a wide variety of virulence lifestyle factors have been shown to be regulated by c-di-GMP. Evidence of the importance of this molecule for bacterial pathogenesis has become so great that new antimicrobial agents are tested for their capacity of targeting c-di-GMP signaling. This review summarizes the current knowledge on this topic and reveals its application for the development of new antivirulence intervention strategies.
PMID: 31500536 [PubMed - in process]

Source: Annual Review of Microbiology - September 7, 2019 Category: Microbiology Authors: Valentini M, Filloux A Tags: Annu Rev Microbiol Source Type: research