Evaluation of Miracle Mouthwash plus Hydrocortisone Versus Prednisolone Mouth Rinses as Prophylaxis for Everolimus‐Associated Stomatitis: A Randomized Phase II Study

Conclusion.Prophylactic use of steroid‐containing oral rinses can prevent/ameliorate mIAS in patients with MBC treated with AIE. MMW + hydrocortisone is an affordable option, as is dexamethasone oral rinse.Implications for Practice.This prospective phase‐II study showed that two steroid‐containing mouthrinses substantially reduced incidences of all‐grade and grade ≥2 stomatitis and related oral adverse events (AEs), and the number of everolimus dose‐delays and/or dose‐reduction in metastatic breast cancer (MBC) patients receiving everolimus treatment plus an aromatase inhibitor. Both oral rinses were well tolerated and demonstrated similar efficacy. Prophylactic use of steroid mouth rinse provides a cost‐effective option that substantially decreases the incidence and severity of mammalian target of rapamycin (mTOR) inhibitor‐associated stomatitis and related oral AEs as well as the need for dose modification in MBC patients undergoing treatment with an mTOR inhibitor.

Source: The Oncologist - September 10, 2019 Category: Cancer & Oncology Authors: Vicky E. Jones, Kristi J. McIntyre, Devchand Paul, Sharon T. Wilks, Sharon M. Ondreyco, Scot Sedlacek, Anton Melnyk, Sanjay P. Oommen, Yunfei Wang, Susan R. Peck, Joyce A. O'Shaughnessy Tags: Symptom Management and Supportive Care, Breast Cancer Source Type: research