IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression

Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associa...

Source: Journal of Experimental and Clinical Cancer Research - September 11, 2019 Category: Cancer & Oncology Authors: Alexander Thiem, Sonja Hesbacher, Hermann Kneitz, Teresa di Primio, Markus V. Heppt, Heike M. Hermanns, Matthias Goebeler, Svenja Meierjohann, Roland Houben and David Schrama Tags: Research Source Type: research