Genomic Triplication of the Glycine Decarboxylase Gene and N-Methyl-D-Aspartate Receptor Hypofunction: Improvement by Glycine and D-Cycloserine

Copy number variation refers to the fact that the number of copies of a particular gene in the genotype may vary among individuals. Rare copy number variants (CNVs) have been implicated in neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder. In this issue of Biological Psychiatry, Bodkin et  al. (1) identified several CNVs spanning 9p24.1 in a proband and his mother whose DSM-IV diagnoses were schizoaffective disorder and bipolar disorder with psychotic features, respectively.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research