Pneumocystis jirovecii infection of bilateral adrenal glands in an immunocompetent adult: a case report.

We report a 48-year-old HIV-negative, diabetic male who presented with fever and adrenal insufficiency. Abdominal sonography and PET-CT revealed bilateral enlarged adrenal glands with peripheral enhancement and central necrosis. An endoscopic ultrasound-guided fine-needle aspiration cytology of the left adrenal gland demonstrated well-defined, round cysts of PJ. There was no evidence of pulmonary involvement. The response to first-line treatment was poor and the patient responded to second-line treatment for Pneumocystis infection. PMID: 31497790 [PubMed - in process]
Source: Journal of the Royal College of Physicians of Edinburgh - Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research

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ConclusionsThe current rapid, multi-slice acquisition and real-time implementation of temperature and displacement visualization may be useful in clinical practices. It may help defining operational safety margins, improving therapy precision and efficacy. Simulations were in good agreement with experimental data and may thus be used prior treatment for procedure planning.
Source: NeuroImage - Category: Neuroscience Source Type: research
ConclusionsOur device represents an improvement and a valid alternative to the current methods diagnosing regional cerebral circulation.Graphical abstract
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
Conclusion: Considering the excellent diagnostic accuracy, ultrasonography can be used as an alternative means in diagnosis of metatarsal bone fractures. PMID: 31602432 [PubMed]
Source: Accident and Emergency Nursing - Category: Emergency Medicine Authors: Tags: Arch Acad Emerg Med Source Type: research
In this study, metal-organic framework-2 (MOF-2) nanomaterial (NM) was synthesized and then coupled with ultrasound (US) process in the presence of peroxydisulfate (S2O82−) for Acid Blue 7 (AB7) degradation as a triarylmethane model dye. The XRD, FT-IR, SEM, TEM, BET, and DRS analyses were utilized to confirm the appropriate formation of nanoporous flake-like MOF-2 with a high specific surface area of 942.6 m2/g. The combined US/MOF-2/S2O82− process demonstrated the highest performance compared to the US and US/S2O82− processes in the same operational conditions. The mentioned processes obeyed pseudo-fi...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Abstract The conventional Drug Delivery System (DDS) has limitations such as leakage of the drug, toxicity to normal cells and loss of drug efficiency, while the stimuli-responsive DDS is non-toxic to cells, avoiding the leakage and degradation of the drug because of its targeted drug delivery to the pathological site. Thus nanomaterial chemistry enables - the development of smart stimuli-responsive DDS over the conventional DDS. Stimuliresponsive DDS ensures spatial or temporal, on-demand drug delivery to the targeted cancer cells. The DDS is engineered by using the organic (synthetic polymers, liposomes, peptide...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
This study aims to explore the role of lncRNAs in the glucometabolic action of metformin on skeletal muscle cells.Main methodsMetformin accumulation was assessed using [14C]-metformin. A lncRNA array was used to investigate metformin-regulated lncRNAs in C2C12 skeletal muscle cells. Knockdown studies were applied to evaluate the function of lncRNA Dreh. A colorimetric assay was used for the measurement of medium glucose concentration; glucose transport was assessed using [3H]-2-deoxyglucose; real-time PCR was used for RNA expression analysis, and western blotting was used to assess protein expression in myotubes. A Dreh ov...
Source: Life Sciences - Category: Biology Source Type: research
Neurological insights into how the brain processes stress, and how it can develop into depression, have led to new interventionsIt ’s a damp, midweek afternoon. Even so, Cardiff’s walk-in stress management course has pulled in more than 50 people. There are teenagers, white-haired older people with walking aids, people from Caucasian, Asian and Middle Eastern backgrounds. There is at least one pair who look like a parent an d child – I’m unsure who is there to support whom.The course instructor makes it clear that she is not going to ask people to speak out about their own stress levels in this firs...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Neuroscience Depression Anxiety Mental health Society Psychology Cities Source Type: news
Publication date: Available online 13 October 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Angelica Patino Gonzalez, Lucy Modahl, Daniel KowalAbstractImaging plays a central role in the diagnosis of pulmonary infections with the chest radiograph as the initial study of choice. CT can further delineate the extent of disease and present key imaging signs that, along with clinical history and laboratory data, can properly guide the differential diagnosis. In this article, we review and illustrate the most relevant CT imaging manifestations of common and less common pulmonary infections, including a section devoted...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
This article provides a foundation for evaluating deep neck infections through a review of essential anatomy and a discussion of important diseases that interact with these spaces.
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Abstract A previously healthy 40-year-old Japanese male was urgently admitted with a 2-month history of dysphagia, 30-kg weight loss, and fever. Human immunodeficiency virus (HIV) antibodies and cytomegalovirus antigenemia were positive. Pneumocystis pneumonia and cytomegalovirus pneumonia were suspected. The patient was diagnosed with acquired immune deficiency syndrome (AIDS). Cytomegalovirus antigenemia became negative 20 days after the positive result. On hospital day 41, he experienced cardiopulmonary arrest. The clinical diagnosis was fulminant type 1 diabetes mellitus. He later developed hypoglycemia and wa...
Source: Acta Med Okayama - Category: Universities & Medical Training Authors: Tags: Acta Med Okayama Source Type: research
More News: Addison's Disease | Adrenal Insufficiency | Cytology | Diabetes | Endocrinology | Fine Needle Aspiration | General Medicine | HIV AIDS | Royal College of Physicians | Ultrasound