A review of antibiotics and psoriasis: induction, exacerbation, and amelioration.

A review of antibiotics and psoriasis: induction, exacerbation, and amelioration. Expert Rev Clin Pharmacol. 2019 Sep 09;: Authors: Tsai YC, Tsai TF Abstract Introduction: Psoriasis is affected by many environmental factors, including infections and antibiotics. However, the relationship between antibiotics and psoriasis is inadequately studied. Some antibiotics were listed as triggering factors; others showed benefit for psoriasis control. The aim of this article is to review current evidence that may help identify appropriate antibiotics for patients with psoriasis. Areas covered: The PubMed, Embase, Clinicalkey databases, and google scholar were searched for relevant articles published up to May 2019. Literature regarding antibiotics and psoriasis were included. Six randomized controlled trials and four controlled or cohort studies were identified in 13 kinds of antibiotics. Expert opinion: Macrolides and rifampin showed decrease of psoriasis score in plaque-type psoriasis, while penicillin revealed no statistically significant improvement in guttate psoriasis. Previously tetracyclines were considered as triggering factors, but data was found only in cases or retrospective studies. Mechanisms were thought to be related to immunomodulation rather than bacteria inhibition. Research gap in the influence of genetic susceptibility, the impact on microbiota, and the mode of actions remain to be investigated. PMID: 31498683 [PubMed - as supplied by publis...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research

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Publication date: Available online 15 October 2019Source: Small Ruminant ResearchAuthor(s): Arpita Mohapatra, Ajay Kumar Shinde, Raghvendar SinghAbstractModern human diet and changes in lifestyle are emerging as a challenge in developing countries resulting to endless ailments. Thus, in modern spectra of human health, bioactive foods play a pivotal role. Under the umbrella of food and nutrition security, functional dairy foods have become the need of the hour. Sheep milk is one of the functionally active dairy foods and it is also considered as nutritional powerhouse. The beneficial role of sheep milk results from its fatt...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Taltz is the first and only IL-17A inhibitor with published clinical trial results in pediatric patients with moderate to severe plaque psoriasis Indianapolis, Oct. 12, 2019 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) announced today that Taltz met co-primary endpoints as well as all major secondary endpoints in a Phase 3 study in pediatric patients with moderate to severe plaque psoriasis, demonstrating that 89 percent of patients treated with Taltz achieved a significant...This story is related to the following:Pharmaceuticals
Source: Industrial Newsroom - Health, Medical and Dental Supplies - Category: Medical Devices Source Type: news
Psoriasis is a chronic autoimmune disease of the skin that is characterized by epidermal thickening and infiltration of immune cells into the skin. It is a T cell mediated disease with a mixed T helper (Th)1/Th17 phenotype [1]. IL-17 is the key mediator of psoriatic inflammation and drives the production of proinflammatory cytokines and chemokines by keratinocytes, and consequently activates leukocytes and recruits them into the skin [2]. Limited data exists regarding the molecular mechanisms underlying the efficacy of narrow-band (NB)-UVB phototherapy combined with balneotherapy (bathing in geothermal seawater, the Blue L...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
AbstractPsoriasis is a prevalent skin disease that impairs multiple domains of quality of life (QoL). Pruritus, a common symptom in patients with psoriasis, may directly affect sleep, but studies investigating this are limited. We investigated the relationships between pruritus and sleep in 104 in-patients with psoriasis, who underwent dermatological assessment and completed questionnaires to determine psoriasis severity, pruritus intensity, sleep quality, QoL (skin disease-specific and generic), depressive mood and anxiety. In total, 80% of patients reported pruritus, and 39% had sleep disturbances, most commonly awakenin...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
The reSURFACE 1 and 2 studies show 4-year benefits with tildrakizumab for patients with moderate to severe plaque psoriasis.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Dermatology News Source Type: news
The reSURFACE 1 and 2 studies show 4-year benefits with the monoclonal antibody for patients with moderate to severe plaque psoriasis.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Dermatology News Source Type: news
Publication date: Available online 14 October 2019Source: Journal of Biomedical InformaticsAuthor(s): Surya Roca, Jorge Sancho, José García, Álvaro AlesancoAbstractChatbots are able to provide support to patients suffering from very different conditions. Patients with chronic diseases or comorbidities could benefit the most from chatbots which can keep track of their condition, provide specific information, encourage adherence to medication, etc. To perform these functions, chatbots need a suitable underlying software architecture. In this paper, we introduce a chatbot architecture for chronic patient ...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
In psoriasis patients, secukinumab mediates its early anti-psoriatic effects by decreasing I κBζ expression and subsequently the expression of IκBζ signature genes. This new finding contributes to our understanding of the pathogenesis of psoriasis.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Fazeli A Abstract Accurate biomarker-based diagnosis of psoriasis vulgaris has remained a challenge; no reliable disease-specific biomarkers have yet been identified. There are several different chronic inflammatory skin diseases that can present similar clinical and dermoscopy features to psoriasis vulgaris, making accurate diagnosis more difficult. Both literature-based and data-driven selection of biomarker was conducted to select candidates for a multicomponent biomarker for psoriasis vulgaris. Support vector machine-based classification models were trained using gene expression data from locally recruited pa...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
AbstractPsoriasis is a chronic inflammatory immune disorder associated with an increased risk of atherosclerosis. This increased risk is not fully understood. High-density lipoproteins (HDL) play an important role in the prevention of atherosclerosis and any factors that may hamper HDL function such as anti-HDL antibodies (aHDL) might be associated with an increased cardiovascular risk. We aimed to determine whether anti-HDL antibodies (aHDL) are present in patients with psoriasis. Sixty-seven patients with psoriasis were compared with a healthy control group. Epidemiologic and clinical data were recorded. IgG and IgM aHDL...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
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