Augmented reality in intradural spinal tumor surgery

ConclusionsMicroscope-based AR can be reliably applied to intradural spinal tumor surgery. Automatic AR registration ensures high precision and provides an intuitive visualization of the extent of the tumor and surrounding structures. Given this setting, all advanced multi-modality options of cranial AR can also be applied to spinal surgery.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research

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ConclusionsIn this population-based study, we developed nomograms that can better help physicians predict the prognosis and survival of ME patients.Legal entity responsible for the studySherief Ghozy.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Funding Opportunity RFA-CA-19-059 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) is intended to continue support for the Pediatric Brain Tumor Consortium (PBTC). This Limited-Competition FOA solicits a single application from the current PBTC awardee. The PBTC was conceived as a dedicated clinical trials organization able to translate innovative therapies from the laboratory to early phase clinical testing so that treatment for primary brain tumors in children can be improved. The importance of the PBTC is highlighted by the continuing high mortality rate among some common brain t...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Conclusion. Based on a large series of our patients with a great variety of histological tumor types, it was concluded, that a neurosurgeon can predict fluorescence sensitivity before surgery.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractObjective5-Aminolevulinic acid (5-ALA) –guided resection of gliomas in adults enables better delineation between tumor and normal brain, allowing improved resection and improved patients’ outcome. Recently, several reports were published regarding 5-ALA for resection of pediatric brain tumors. The aim of the study was to determine th e intracellular fluorescence of protoporphyrin IX (PPIX) in pediatric brain tumors by hyperspectral imaging and to compare it with visually observed intraoperative fluorescence.Methods5-ALA was administered orally 4  h prior to surgery. During tumor resection, the surg...
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research
Conditions:   Glioblastoma;   Medulloblastoma;   Ependymoma;   Diffuse Intrinsic Pontine Glioma Interventions:   Drug: Indoximod;   Radiation: Partial Radiation;   Radiation: Full-dose Radiation;   Drug: Temozolomide;   Drug: Cyclophosphamide;   Drug: Etoposide;   Drug: Lomustine Sponsors:   Theodore S. Johnson;   Emory University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Due to the relatively few number or clinical studies, prospective clinical trials are needed to increase the overall level of evidence concerning the usage of 5-ALA in CNS tumors different from high-grade glioma. Furthermore, a greater us of new tools such as, spectroscopy or confocal microscope or the use of combination of other fluorescence could make more effective this technique. PMID: 31355622 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
Abstract Being the fourth leading cause of cancer-related death, glial tumors are highly diverse tumor entities characterized by important heterogeneity regarding tumor malignancy and prognosis. However, despite the identification of important alterations in the genome of the glial tumors, there remains a gap in understanding the mechanisms involved in glioma malignancy. Previous research focused on decoding the genomic alterations in these tumors, but due to intricate cellular mechanisms, the genomic findings do not correlate with the functional proteins expressed at the cellular level. The development of mass sp...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
AbstractMosaic somatic mutations in the isocitrate dehydrogenase 1/2 (IDH1/2) genes have been identified in most enchondromas by targeted mutation analysis. Next-generation sequencing (NGS), that may detect even low-level mosaic mutation rates, has not previously been applied to enchondromas. Immunohistochemistry using the H09 clone is routinely used as a surrogate for the common R132HIDH1 mutation in gliomas. We compared immunohistochemistry and NGS results in a series of 13 enchondromas from 8 pediatric patients. NGS identified a heterozygousIDH mutation in all enchondromas, showing identical mutation status in patients ...
Source: Virchows Archiv - Category: Pathology Source Type: research
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