Battery obsolescence, industry profit and deep brain stimulation

Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research

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Publication date: Available online 14 October 2019Source: MethodsXAuthor(s): Antti Huotarinen, Sakari Leino, Raimo K. Tuominen, Aki LaaksoAbstractIn experimental deep brain stimulation of the subthalamic nucleus (STN HFS), stimulation currents just below the appearance threshold of stimulation-induced dyskinesias has often been used. The behavioral effect of STN HFS can be measured by the reversal of forelimb use asymmetry produced by hemiparkinsonism can be measured with the cylinder test among other tests. We used 18 Wistar rats with 6-hydroxydopamine induced hemiparkinsonism to test a customized scale to rate the severi...
Source: MethodsX - Category: Science Source Type: research
Researchers here report on a small clinical trial of a form of electromagnetic stimulation, claiming reduction in amyloid burden and improvement in cognitive function in Alzheimer's patients. Other approaches to electromagnetic stimulation have been tested in human trials for Alzheimer's disease and failed; the authors here argue that the details of the methodology used matter greatly. It is not unreasonable to expect electromagnetic fields to have effects on cellular metabolism, and there are a range of efforts to try to affect everything from neurodegeneration to wound healing via this class of approach. There is always ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Although subthalamic Deep Brain Stimulation (STN DBS) is proven effective in improving symptoms of Parkinson's Disease (PD), previous literature demonstrates a discrepancy between objective improvement and patients' perception thereof. We aimed to examine whether postoperative stimulation challenge tests (SCT) alters patients' satisfaction after STN DBS for PD.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Short communication Source Type: research
Conclusions: In>8 years of observation, most participants experienced a robust and sustained antidepressant response to SCC DBS. News in Context: Ethical issues raised around deep brain stimulation (DBS) research Closing the Circuit: Helen Mayberg’s research could revolutionize depression treatment Expo Day: Neuroenginnering, BPI, Arrowsmith Program &ARPF from SharpBrains
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology antidepressant area-25 brain pacemaker brain stimulation DBS deep-brain-stimulation depression Helen-Mayberg neurosurgical treatment Source Type: blogs
In a double-blind randomized crossover trial, we previously established that bilateral deep brain stimulation of the anteromedial globus pallidus internus (GPiam-DBS) is effective in significantly reducing tic severity in patients with refractory Tourette syndrome (TS). Here, we report the effects of bilateral GPiam-DBS on cognitive function in 11 of the 13 patients who had participated in our double-blind cross-over trial of GPi-DBS.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Short communication Source Type: research
CONCLUSIONS: QSM-based images allow for confident localization of borders of the GPi that is superior to T1w and T2w images. High-contrast hybrid images can be used for precisely directed DBS targeting, e.g., GPi DBS for the treatment of advanced Parkinson's disease. PMID: 31604332 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
CONCLUSIONS: Intraoperative MRI-guided lead placement in patients with dystonia showed improvement in clinical outcomes comparable to previously reported results using awake MER-guided lead placement. The accuracy of lead placement was high, and the procedure was well tolerated in the majority of patients. However, a number of patients experienced serious adverse events that were attributable to the introduction of a novel technique into a busy neurosurgical practice, and which led to the revision of protocols, product inserts, and on-site training. PMID: 31604331 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Abstract Over the last two decades, deep brain stimulation (DBS) has gained popularity as a treatment of severe and medically refractory obsessive-compulsive disorder (OCD), often using brain targets informed by historical lesional neurosurgical procedures. Paradoxically, the use of DBS in OCD has led some multidisciplinary teams to revisit the use of lesional procedures, especially anterior capsulotomy (AC), although significant aversion still exists toward the use of lesional neurosurgery for psychiatric disorders. This paper aims to review all literature on the use of AC for OCD to examine its effectiveness and...
Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
Deep brain stimulation (DBS) typically has been delayed until late stage of Parkinson's disease (PD), a mean of 14 –15 years after diagnosis. EARLYSTIM study applied DBS in patients with PD presenting motor complications for less than three years, and showed that early stimulation offered greater benefit than best medical therapy in all primary and major secondary end points. Based on the results of EARLYSTIM study, the U.S. Food and Drug Administration recently approved DBS for use in people with PD of at least four years duration and with recent onset of motor complications.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Point of view Source Type: research
Deep brain stimulation (DBS) of a region called the subcallosal cingulate appears to be safe and effective at reducing symptoms of depression in patients with treatment-resistant depression over time, according to asmall study inAJP in Advance.Previous studies suggest that up to one-third of all patients with major depression have treatment-resistant depression (that is, they fail to experience symptom improvements during two or more antidepressant trials). “Given that patients with treatment-resistant depression are highly susceptible to recurrent depressive episodes, the ability of DBS or any treatment to support l...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance Andrea Crowell bipolar disorder DBS deep brain stimulation functioning HAM-D subcallosal cingulate surgery treatment-resistant depression Source Type: research
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