Lost after translation: post-translational modifications by bacterial type III effectors.

Lost after translation: post-translational modifications by bacterial type III effectors.
Curr Opin Microbiol. 2013 Apr;16(2):213-20
Authors: Salomon D, Orth K
Abstract
Many Gram-negative bacterial pathogens use the type III secretion system to deliver effector proteins into host cells. These effectors use various mechanisms to exploit host processes to the advantage of the pathogen. A large group of effectors use post-translational modifications, either reversible or irreversible, to manipulate host proteins, and while most of these mechanisms mimic eukaryotic activities, others appear to be unique biochemical functions. Deciphering such mechanisms and identifying the host targets of these effectors sheds light on eukaryotic signaling pathways and immune responses.
PMID: 23466212 [PubMed - in process]

Source: Current Opinion in Microbiology - April 1, 2013 Category: Microbiology Authors: Salomon D, Orth K Tags: Curr Opin Microbiol Source Type: research