Early Life Predictors of Systolic Blood Pressure Trajectories from Infancy to Adolescence: Findings from Project Viva.

Early Life Predictors of Systolic Blood Pressure Trajectories from Infancy to Adolescence: Findings from Project Viva. Am J Epidemiol. 2019 Sep 09;: Authors: Aris IM, Rifas-Shiman SL, Li LJ, Belfort MB, Hivert MF, Oken E Abstract Childhood blood pressure (BP) is a strong predictor for later cardiovascular risk. However, few studies have assessed dynamic BP trajectories throughout the early life period. We investigated the relationship between early life factors and systolic BP (SBP) from infancy to adolescence using linear spline mixed-effect models among 1370 children from Project Viva, a Boston-area cohort recruited in 1999‒2002. After adjusting for confounders and child height, we observed higher SBP in children exposed to gestational diabetes [vs. normoglycemia‒at 3 years: β 3.16mmHg (95% confidence interval 0.28,6.04); 6 years: 1.83mmHg (0.06,3.60)], hypertensive disorders of pregnancy [vs. normal maternal BP‒at 6 years: 1.39mmHg (0.10,2.67); 9 years: 1.84mmHg (0.34,3.34); 12 years: 1.70mmHg (0.48,2.92)], higher neonatal SBP [per 10mmHg increase‒at 3 years: 1.26mmHg (0.42,2.09); 6 years: 1.00mmHg (0.49,1.51); 9 years: 0.75mmHg (0.17,1.33)] and formula milk in the first 6 months [vs. breastmilk only‒at 12 years: 2.10mmHg (0.46,3.74); 15 years: 3.52mmHg (1.40,5.64); 18 years: 4.94mmHg (1.88,7.99)]. Our findings provide evidence of programming of offspring SBP trajectories by gestational diabetes, hypertensive disorders ...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research