Effects of lung deflation induced by tiotropium/olodaterol on the cardiocirculatory responses to exertion in COPD

Hyperinflation has been associated with negative cardiocirculatory consequences in patients with chronic obstructive pulmonary disease (COPD). These abnormalities are likely to worsen when the demands for O2 increase, e.g., under the stress of exercise. Thus, pharmacologically-induced lung deflation may improve cardiopulmonary interactions and exertional cardiac output leading to higher limb muscle blood flow and oxygenation in hyperinflated patients with COPD.

Source: Respiratory Medicine - September 9, 2019 Category: Respiratory Medicine Authors: Danilo C. Berton, Renata D. Marques, Brandon Palmer, Denis E. O'Donnell, J.Alberto Neder Source Type: research