Sanofi to pay Lexicon $260 million for terminated partnership

Lexicon Pharmaceuticals Inc said on Tuesday France's Sanofi SA will pay the drugmaker $260 million for the termination of their partnership to develop diabetes drug Zynquista.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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ConclusionsComparisons of CABG characteristics and outcomes were conducted between the STS National Database and JCVSD to illustrate the value of international collaboration off adult cardiac surgery databases.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Yang X Abstract Diabetic nephropathy (DN) is a serious complication of diabetes mellitus whose expand process is linked with the fibrosis, renal hypertrophy and inflammation. The current study was to formulate and optimize the nano-formulation of crocetin (CT-PLGA-NPs) against Streptozotocin-induced renal nephropathy in rats. Double emulsion evaporation technique was used for the preparation of CT-PLGA-NPs. CT-PLGA-NPs were scrutinized for polydispersity index, size, gastric stability, entrapment, drug-loading capacity and in-vitro drug release and in vivo preclinical study. Single intraperitoneal injectio...
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Findings based on survey of university - affiliated students, staff with either type 1 or type 2 diabetes
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Endocrinology, Family Medicine, Internal Medicine, Nursing, Pediatrics, Psychiatry, Journal, Source Type: news
Authors: Iyer KS, Dayal S Abstract Platelets are small, anucleated effector cells that play an important role in linking the hemostatic and inflammatory processes in the body. Platelet function is known to be altered under various inflammatory conditions including aging. A gain in platelet function during aging can increase the risk of thrombotic events, such as stroke and acute myocardial infarction. Anti-platelet therapy is designed to reduce risk of serious cerebrovascular and cardiovascular events, but the adverse consequences of therapy, such as risk for bleeding increases with aging as well. Age-associated co...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
CONCLUSION: Gingival recession is a common finding in the Colombian population. Factors associated with recession presence were the same as for periodontitis. Less frequent toothbrushing was associated with deep buccal recession. PMID: 31522165 [PubMed - in process]
Source: Journal of the International Academy of Periodontology - Category: Dentistry Tags: J Int Acad Periodontol Source Type: research
ConclusionsMore frequent and regular primary care provider encounters are associated with an increased likelihood of non-insulin diabetes medication adherence. These findings contribute to data needed to establish evidence-based guidelines for primary care provider encounter cadence for those newly diagnosed with type 2 diabetes mellitus.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionGroup B streptococcal infection might become invasive in immunocompromised patients, so careful follow-up for those patients is important.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 17 September 2019Source: Science &SportsAuthor(s): M. Kordi, S. Khoramshahi, S. Eshghi, A. Gaeeni, A. MoosakhaniSummaryAimsMuscle atrophy is one of the complications of people with diabetes. Exercise have reversing effect of muscle atrophy in various conditions, hence the aim of the study was to evaluate The effect of five weeks of high intensity interval training (HIIT) on the expression of Atrogin-1, miR-23a, miR-206 and myostatin in gastrocnemius muscles of diabetic rats.MethodsFor this purpose, diabetes was induced in 14 Wistar male rats with an average weight of 260 ±...
Source: Science and Sports - Category: Sports Medicine Source Type: research
In conclusion, it is only through a series of tests taking many endogenous and exogenous parameters into account, some of which are hardly controllable, that a glycemic balance can be attained and high level sports performances can be achieved.
Source: Science and Sports - Category: Sports Medicine Source Type: research
Conditions:   Diabetes Mellitus;   Diabetes Mellitus, Type 2;   Obesity;   Body Weight;   Bone Diseases, Metabolic;   Fractures, Bone;   Osteoporotic Fractures;   Osteoporosis;   Quality of Life;   Fall;   Musculoskeletal Diseases Intervention:   Sponsors:   Suzanne Morin;   CHU de Quebec-Universite Laval Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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