Long-Term Efficacy of Vismodegib After its Withdrawal and Patients ’ Health-Related Quality of Life Using the Dermatology Life Quality Index (DLQI)

ConclusionThe results of this exploratory analysis of vismodegib withdrawal are consistent with a substantial link between treatment response and patients ’ HRQoL. Furthermore, 11 out of 35 (31%) patients that reported a complete remission of the disease after 6 months of vismodegib treatment reported BCC recurrence. These data highlight the importance of continuous follow-up and perhaps different regimens of treatment, such as an alternate dose re gimen to maintain disease control and reduce the adverse events as previously described in the literature.
Source: Dermatology and Therapy - Category: Dermatology Source Type: research

Related Links:

Authors: Schipani G, Del Duca E, Todaro G, Scali E, Dastoli S, Bennardo L, Bonacci S, Di Raimondo C, Pavel AB, Colica C, Xu X, Procopio A, Patruno C, Nisticó SP Abstract BACKGROUND: The role of heavy metals in carcinogenetic process has been widely established however, information on the most common environmental metals that serve as major risk factors for actinic keratosis (AK)/non-melanoma skin cancer (NMSC) are still lacking. We aim to evaluate levels of the most common environmental heavy metals in hair of patients with AK/NMSC as compared to healthy controls. METHODS: 31 patients diagnosed with AK/N...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
CONCLUSION: The preferred method for reconstruction after orbital exenteration in our university affiliated center is lateral frontal galeal-cutaneous flap based on superficial temporal artery. The flap harvesting is simple, safe and obtains enough tissue for covering defects even after extended exenteration. Complication rate is low. We suggest the simultaneous use of this flap with pedicle temporalis muscle flap only for reconstruction of scull base after anterior cranial fossa resection. PMID: 32927925 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Martens MC, Emmert S, Boeckmann L Abstract Sunlight, in particular UV-B radiation, is an important factor for endogenous vitamin D production as 80-90% of the required vitamin D needs to be photosynthesized in the skin. The active form of vitamin D, vitamin D3 or calcitriol, binds to the ligand-activated transcription factor vitamin D receptor (VDR) for genomic and non-genomic effects. Recently, calcitriol and analogs have been shown to have antiproliferative effects in mouse and human BCC and SCC cell lines in vitro. As UV radiation plays a critical role in the photosynthesis of vitamin D, stringent sun p...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Boeckmann L, Martens MC, Emmert S Abstract The prevalent keratinocyte-derived neoplasms of the skin are basal cell carcinoma and squamous cell carcinoma. Both so-called non-melanoma skin cancers comprise the most common cancers in humans by far. Common risk factors for both tumor entities include sun exposure, DNA repair deficiencies leading to chromosomal instability, or immunosuppression. Yet, fundamental differences in the development of the two different entities have been and are currently unveiled. The constitutive activation of the sonic hedgehog signaling pathway by acquired mutations in the PTCH a...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Purpose of review To inform pediatric providers of the clinical characteristics, underlying genetic drivers, and therapeutic options for skin cancer arising in childhood and adolescence. Recent findings The incidence of melanoma in pediatric patients has been declining in the past decades. Pediatric-specific diagnostic criteria should be utilized when assessing lesions concerning for melanoma to better account for the different presentations seen in pediatric disease compared with adults, such as an increased prevalence of amelanotic melanoma or frequent mimic of benign pediatric lesions. Pediatric melanoma often pres...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: DERMATOLOGY: Edited by Albert C. Yan Source Type: research
Background Psoriasis is a chronic inflammatory skin disorder which may result in an increased cancer risk due to defects of immune surveillance. The relationship between psoriasis and risk of non-melanoma skin cancer (NMSC) has not yet been fully determined. The aim of this study was to update the evidence on the association between psoriasis and risk of NMSC.Methods We conducted an extensive literature search of publications in Pubmed, EMBASE, and Cochrane Library without restrictions on language from inception through August 2019 using predefined keywords. Eligible observational studies were selected if they assessed the...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Conclusion: Skin cancer prevalence and incidence is increasing worldwide. In our study, BCC was the most common type of skin cancer to be reported in our institute, which is similar to the majority of other international studies. PMID: 32601638 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Authors: Maraee A, Farag AGA, Gadallah MM, Abdou AG Abstract Non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) represents 78.5% of all skin malignant tumours in Egypt. Dendritic cells can be found in almost all human tumours, they play an important role in antitumour immunity. The aim of the present study was to evaluate the percentage of Langerhans cells using CD1a in non-melanoma skin cancer, including BCC and SCC and to correlate this percentage with their clinicopathological features. The current study was performed on surgically excised specimens of 41 patients pr...
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
Melanoma and non-melanoma skin cancers (NMSCs) are two major forms of skin cancers. Melanoma is the most aggressive form of skin cancer related deaths while basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are most prevalent forms of NMSCs with over 5.3million yearly cases in the US. Due to huddles including resistance, bioavailability and adverse effects with available treatments, there is the need for effective strategies against skin cancer progression. The cyclin dependent kinase-2(CDK2), c-kit and mammalian target of rapamycin (mTOR), are attractive targets for new anticancer drug development.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pharmacology and Drug Development Source Type: research
Background: Moh ’s micrographic surgery (MMS) is the gold standard treatment for non-melanoma skin cancers (NMSC) such as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Despite the advantages of MMS, the technique also has limitations. The procedure can be time-consuming and, due to the bulky natur e of many cutaneous tumors, appropriately sectioning and flattening the specimen for cryosection without omitting tissue is difficult. A novel method has recently been proposed as an alternative to the traditional MMS approach.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Translational Studies Source Type: research
More News: Basal Cell Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Dermatology | Italy Health | Melanoma | Nonmelanoma Skin Cancer | Skin | Skin Cancer | Study