Albuminuria: Associated with Heart Failure Severity and Impaired Clinical Outcomes

Publication date: Available online 9 September 2019Source: Canadian Journal of CardiologyAuthor(s): Mony Shuvy, Donna R. Zwas, Chaim Lotan, Andre Keren, Israel GotsmanAbstractBackgroundUrinary albumin to creatinine ratio (UACR) is common in patients with heart failure (HF) and may have an impact on clinical outcome. We evaluated the effect of UACR on clinical outcome in a real-world cohort of patients with HF.MethodsAll patients with HF at a health maintenance organization were followed for cardiac-related hospitalizations and death.ResultsThe study cohort included 4,668 HF patients and was divided into 3 groups based on UACR: normal range albuminuria (2,085 patients; 45%), microalbuminuria (1,769 patients; 38%), and macroalbuminuria (814 patients; 17%). Microalbuminuria and macroalbuminuria were both associated with increasing age, diabetes mellitus, hypertension, peripheral vascular disease, atrial fibrillation, and NYHA class III/IV. Microalbuminuria and macroalbuminuria were directly associated with decreased event-free survival from death as well as death and cardiovascular-hospitalizations. Cox regression analysis after adjustment for significant predictors demonstrated that microalbuminuria was associated with increase in mortality (hazard ratio (HR) 1.18, 95% CI 1.18-1.38, P=0.03) and macroalbuminuria (HR 1.33, 95% CI 1.10-1.61, P
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research

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