Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice.

CONCLUSIONS: We conclude that activation of endothelial Rac1 improves functional recovery and angiogenesis after stroke, and this process is mediated by Pak1 signaling. This study provides novel insight for Rac1 in the mechanism of long-term stroke recovery. PMID: 31499064 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31499064?dopt=Abstract

Source: Experimental Neurology - September 5, 2019 Category: Neurology Authors: Bu F, Min JW, Munshi Y, Lai YJ, Qi L, Urayama A, McCullough LD, Li J Tags: Exp Neurol Source Type: research