Blood lead level: an overlooked risk of carpal tunnel syndrome in hemodialysis patients.

Blood lead level: an overlooked risk of carpal tunnel syndrome in hemodialysis patients. Ren Fail. 2019 Nov;41(1):786-793 Authors: Huang WH, Hu CC, Yen TH, Hsu CW, Weng CH Abstract Introduction: Carpal tunnel syndrome (CTS) is a severe complication observed in long-term maintenance hemodialysis (MHD) patients. The most common cause of CTS is dialysis-related β2-microglobulin amyloidosis, which is associated with inflammation and oxidative stress in dialysis patients. Patients on MHD have higher blood lead levels (BLLs) than the general population. Lead (Pb) exposure in chronic dialysis patients has been noted to induce oxidative stress and inflammation. Therefore, lead-related inflammation and oxidative stress might contribute to CTS. Methods: The medical records of 866 MHD patients were reviewed. Two hundred and thirty-four patients with symptoms of CTS were surveyed by senior neurologists via physical examinations and nerve conduction studies. Patients in this study were stratified into groups with low-normal (20 μg/dL) BLLs. The associations between CTS and BLLs and the clinical data were analyzed. Results: Multivariate logistic regression analyses showed that Log BLL (OR: 54.810, 95% CI: 13.622-220.54, p 
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research

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Publication date: Available online 12 October 2019Source: Journal of Membrane ScienceAuthor(s): Moshe Herzberg, Soumya Pandit, Meagan S. Mauter, Yoram OrenAbstractIon exchange membranes (IEMs) often suffer from biofouling, which reduces ion exchange rates and increases energy consumption in water treatment processes, such as electrodialysis, reverse electrodialysis, membrane capacitive deionization, and Donnan dialysis, and in energy devices, such as microbial fuel cells. In the present study, microbial biofilm formation was studied on anion exchange membranes (AEMs) and a cation exchange membranes (CEMs) of the homogeneou...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Authors: AktaƟ A, Karadavut M, Cansu DÜ, Korkmaz C Abstract OBJECTIVES: To evaluate differences between the patients with familial Mediterranean fever (FMF) with homozygous (Hom), heterozygous (Het) and compound heterozygous (cHet) MEFV mutations in terms of clinical features and severity of the disease, as well as frequency of concomitant disorders, without focusing on Exon 10 mutations. METHODS: The patients with FMF were diagnosed using the Tel-Hashomer diagnostic criteria. The presence of MEFV mutations was investigated in exons 2,3,5 and 10 by multiplex-PCR reverse hybridisation method. All the patie...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Salguero MV, Al-Obaide MAI, Singh R, Siepmann T, Vasylyeva TL Abstract Lipopolysaccharide (LPS), a potent endotoxin present in the outer membrane of Gram-negative bacteria, causes chronic immune responses associated with inflammation. In the present study, the association between LPS and the dysbiosis of Gram-negative bacteria in the gut microbiome was determined in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (T2DM-CKD; stages 4 and 5, not on dialysis) compared with healthy individuals. Microbiome diversity was analyzed in patients with T2DM-CKD and healthy controls by sequenci...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Ghersin I, Abu Alheija O, Azzam ZS, Nasser R PMID: 31599514 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
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Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
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Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
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Source: Burns - Category: Dermatology Source Type: research
We present the case of an 84-year-old man with chest tightness, dyspnoea, and ascites. He had a history of dyslipidaemia and ischaemic heart disease. Initial investigations showed severe diastolic dysfunction and elevated pulmonary artery systolic pressure on echocardiogram along with elevated serum natriuretic peptides. Further evaluation by a magnetic resonance imaging scan of the heart and endomyocardial biopsy confirmed the diagnosis of senile systemic amyloidosis. He made good progress after treatment with conventional heart failure drugs and is currently under consideration to start on specific medications to slow do...
Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
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Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
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